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Emergence of a New Pathogen: A Retrospective Study of HPeV-5 Central Nervous System Disease in Alberta, Canada.
Viruses
October 2024
Department of Pediatrics, Alberta Children's Hospital, University of Calgary, Calgary, AB T3B 6A8, Canada.
Article Synopsis
- Human parechoviruses (HPeVs) are significant causes of central nervous system infections in neonates, with a study conducted in Alberta from 2014 to 2019 focusing on HPeV-3 and the emerging HPeV-5 strains.
- Among the 18,882 cerebrospinal fluid samples tested, 56 were positive for HPeVs, with a higher prevalence in 2016 and a notable spike in infections during late summer to fall.
- The study found differences in mean ages of infection (18 days for HPeV-5 vs. 26 days for HPeV-3), and genetic sequencing suggested similarities with a recombinant strain identified in Australia, highlighting the need for ongoing research
Article Synopsis
- Acrodermatitis enteropathica is a rare condition marked by dermatitis, hair loss, and diarrhea, often linked to zinc deficiency, which can occur due to poor diet or complications from parenteral nutrition.
- A 5-year-old child who had been on total parenteral nutrition for a month developed symptoms including skin lesions and extremely low zinc levels, which were found after a challenging diagnosis due to other existing health issues.
- After starting zinc supplementation, the child's condition improved rapidly, highlighting the importance of trace elements in parenteral nutrition and the need to consider acrodermatitis enteropathica in similar cases.
Acute Coxsackievirus B3-induced meningo-cerebellitis in an immunocompetent adult patient.
J Neurovirol
December 2022
Service de Médecine Interne, Maladies Infectieuses, Immunologie Clinique, CHU de Reims, 51092 Cedex, Reims, France.
We report an acute Coxsackievirus B3 (CVB3)-induced meningo-cerebellitis in an immunocompetent adult patient. CVB3 has a global distribution and is the most common Enteroviruses cause of myocarditis and sudden cardiac death. To our knowledge, CVB3 is exceedingly rare as causes of meningo-encephalitis in immunocompetent adults, whereas some cases have been reported in neonates due to perinatal acquired infections or in immunocompromised patients.
View Article and Find Full Text PDFinfections: presentation, diagnosis and treatment.
Br J Hosp Med (Lond)
October 2021
Department of Pharmacy, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.
Listeriosis is an infective complication that primarily affects pregnant women, patients at extremes of age or those with weakened immune systems. Ingestion of food contaminated with is the most common source of infection, causing self-limiting illness in immunocompetent hosts but associated with invasive infection and high mortality in high-risk patient groups. Milder illness presents as gastroenteritis with fever, diarrhoea, nausea and vomiting common in the 7 days post exposure.
View Article and Find Full Text PDFTransient hypothyroidism associated with viral Human Parechovirus encephalitis in a newborn.
Eur J Paediatr Neurol
November 2015
Neonatal Intensive Care Unit, University Hospitals Leuven, Herestraat 49, B-3000 Leuven, Belgium.
Human Parechovirus type 3 (HPeV-3) is a neurotropic virus which can cause neonatal encephalitis, presenting as encephalopathy with seizures and diffuse white matter lesions on brain imaging. Neurodevelopmental outcome is linked to the extent of white matter abnormalities. We report on a neonate with clinical and biochemical findings of transient central hypothyroidism associated with HPeV-3 encephalitis.
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