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Cutaneous natural killer/T-cell lymphoma. | LitMetric

Cutaneous natural killer/T-cell lymphoma.

J Am Acad Dermatol

Department of Dermatology, Yale Dermatopathology Laboratory, Yale University School of Medicine, 15 York Street, New Haven, CT 06520-8059, USA.

Published: March 2002

Lymphomas are classified as either Hodgkin's or non-Hodgkin's. The 2 subtypes of non-Hodgkin's lymphoma that can present primarily in the skin are cutaneous T-cell lymphoma and cutaneous B-cell lymphoma, both of which tend to be low-grade malignant neoplasms. Recently another distinct subtype of lymphoma was discovered, the natural killer (NK)/T-cell lymphoma, which can involve the skin in a primary or secondary fashion. The NK/T-cell subtype of lymphoma is characterized by the expression of the NK-cell antigen CD56. These CD56(+) lymphomas are further subdivided into nasal NK/T-cell lymphomas that commonly present as midfacial destructive disease and non-nasal NK/T-cell lymphomas that often arise in extranodal locations, including the skin. We report a case of aggressive NK-cell leukemia/lymphoma with numerous secondary cutaneous lesions and review the clinical and histopathologic spectrum of non-nasal CD56(+) lymphomas, with an emphasis on the dermatologic findings.

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Source
http://dx.doi.org/10.1067/mjd.2002.118339DOI Listing

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