Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Downmodulation of potassium conductances induces epileptic seizures in cortical network models via multiple synergistic factors.
J Neurosci
January 2025
Department of Neuroscience, Brown University, Providence RI, USA.
Voltage-gated potassium conductances [Formula: see text] play a critical role not only in normal neural function, but also in many neurological disorders and related therapeutic interventions. In particular, in an important animal model of epileptic seizures, 4-aminopyridine (4-AP) administration is thought to induce seizures by reducing [Formula: see text] in cortex and other brain areas. Interestingly, 4-AP has also been useful in the treatment of neurological disorders such as multiple sclerosis (MS) and spinal cord injury, where it is thought to improve action potential propagation in axonal fibers.
View Article and Find Full Text PDFConfined CHA-HCR system for sensitive and specific detection of ANXA2 mRNA in adenomyosis tissues.
J Pharm Biomed Anal
January 2025
Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian 350005, China; FujianKey Laboratory of Women and Children's Critical Diseases Research, Fuzhou, Fujian 350005, China. Electronic address:
Isothermal, enzyme-free amplification techniques, such as the hybridization chain reaction (HCR) and catalytic hairpin assembly (CHA), have gained significant attention for mRNA analysis. Despite their potential, these methods still face challenges, including false positives and low amplification efficiency. To overcome these limitations, we have developed a confined catalytic hairpin assembly and hybridization chain reaction (CHA-HCR) system that utilizes cholesterol-modified hairpin probes to enhance the sensitivity and specificity of mRNA detection.
View Article and Find Full Text PDFAn integrated and multifunctional homemade cell sensor platform based on Si-d-CQDs and CRISPR-Cas12a for CD31 detection during endothelial-to-mesenchymal transition.
Talanta
January 2025
Department of Laboratory Medicine, Taihe hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, China; Hubei Key Laboratory of Embryonic Stem Cell research, Hubei University of Medicine, Shiyan, 442000, Hubei, China; Clinical molecular diagnostic center, Taihe hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, China. Electronic address:
Endothelial-to-mesenchymal transition (EndMT) plays a crucial role in the initiation and progression of atherosclerosis and various disease processes. Cluster of differentiation 31 (CD31) is a significant marker in EndMT. Detecting CD31 is essential for early-stage monitoring of EndMT and diagnosing atherosclerosis.
View Article and Find Full Text PDFComputed tomography-based prediction of interval cytoreduction in advanced ovarian cancer.
Int J Gynecol Cancer
January 2025
Subdirección de Investigación Básica, Instituto Nacional de Cancerología, Tlalpan, Mexico City, Mexico. Electronic address:
Objective: Our retrospective study aimed to investigate the role of computed tomography (CT) using both the tomographic Fagotti index and the Sugarbaker peritoneal cancer index (PCI) in predicting the feasibility of optimal interval debulking surgery in epithelial ovarian cancer.
Methods: Patients with advanced ovarian cancer treated in our institution who were eligible for interval debulking surgery were identified and included in the study. A retrospective image collection was operated, and CT scan evaluations were conducted by 2 independent radiologists to establish both scores (Fagotti index and Sugarbaker PCI).
We present a novel and efficient methodology for obtaining high-gain on-chip few-mode erbium-doped waveguide amplifiers, which exhibit a moderate differential mode gain (DMG). The efficiency of the device is validated by an optimized algorithm that theoretically models the gain performance of the six lowest-order optical modes, namely TE, TM, TE, TM, TE, and TM. Notably, these six signal modes achieve internal net gains exceeding 22 dB within a 5-cm-long waveguide, while maintaining the DMG at a mere 2 dB.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!