From the aerial parts of Teucrium montbretii subsp. libanoticum 10 neoclerodane diterpenoids were isolated. Three of them are new [3beta-hydroxyteubutilin A (1), 12-epi-montanin G (2), 20-epi-3,20-di-O-deacetylteupyreinidin (3)], whereas the other seven, namely, 6-ketoteuscordin (4), teuscordinon (5), 6beta-hydroxyteuscordin (6), montanin D (7), 3,20-di-O-deacetylteupyreinidin (8), montanin G (9), and 3-O-deacetylteugracilin A (10), are previously known structures. The structures of 1-3 were determined by spectral and chemical methods.
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http://dx.doi.org/10.1021/np010303m | DOI Listing |
Nat Prod Bioprospect
January 2025
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, People's Republic of China.
Teucrifarides A-D (1-4), four previously unreported neo-clerodane-type diterpenoids, combined with sixteen known analogs (5-20), were purified from Teucrium quadrifarium. The absolute forma of compounds 1-4 were determined via spectroscopic and ECD calculation methods, together with X-ray crystallography experiments. Among them, compound 1 possessed a 5,20-epoxy ring featuring a unique cage-like 12-oxatricyclo [5.
View Article and Find Full Text PDFSmall Methods
January 2025
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China.
Chin J Nat Med
November 2024
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Key Laboratory of Research and Development for Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming 650500, China; Southwest United Graduate School, Kunming 650592, China. Electronic address:
Two new nor-ent-halimane diterpenes and three previously unreported nor-clerodane diterpenes, designated callicaintides A-E (1-5), were isolated from Callicarpa integerrima. Compounds 1 and 2 feature a distinctive 5/6-membered ring system, while compounds 3-5 are characterized by progressively truncated carbon skeletons, containing 18, 17, and 16 carbons, respectively. In addition, four known compounds 6-9 were also identified.
View Article and Find Full Text PDFHeliyon
October 2024
Institute of Chemistry, São Paulo State University, UNESP, Francisco Degni 55, 14800-900, Araraquara, SP, Brazil.
Sw. (Salicaceae) is noted for its morphological and chemical plasticity and pharmacological properties. The present study investigates two of its varieties: var.
View Article and Find Full Text PDFFitoterapia
December 2024
The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China. Electronic address:
Three new neoclerodane diterpenoids (1-3), two new steroids (4-5), one new monoterpene (6), one new derivative of benzaldehyde (7) and one new iridoid glycoside (8), along with 19 known phenolic compounds, were isolated from Clerodendrum trichotomum. Their structures were established by a combination of detailed spectroscopic analyses (1D and 2D NMR) and high resolution electrospray ionization mass spectroscopy (HRESIMS). The isolated compounds were screened on α-glucosidase inhibitory and the peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist activities, and the results showed that three phenylethanoid glycosides, verbascoside (9), leucosceptoside a (10), and isoacteoside (13), and two flavonoids, apigenin (22) and luteolin (26) showed potent inhibitory effects against α-glucosidase, with IC values in the range from 15 to 700 μM.
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