AI Article Synopsis
- A patient exhibited nodular liquefying panniculitis and polyarthritis alongside an undetected pancreatic tumor, with skin lesions initially misidentified as erythema nodosum.
- The analysis of subcutaneous and synovial fluids revealed identical rectangular particles that were negatively birefringent, suggesting a possible link between the two conditions.
- Serum lipase levels were consistently high but did not correlate with disease activity, and no biochemical signs of lipolysis were found in the fluids, indicating that immune mechanisms were likely not responsible for the patient's condition.
Article Abstract
A patient with nodular liquefying panniculitis, polyarthritis and an occult pancreatic neoplasm is described. The skin lesion was initially mistaken for erythema nodosum. Subcutaneous and synovial fluids demonstrated similar negatively birefringent, rectangular particles, lying in between fat globules. Serum lipase,although continuously elevated, did not fluctuate with disease activity. Biochemical evidence of lipolysis in either the synovial fluid or serum was not demonstrable. Immunologic mechanisms appeared not to be involved in the pathogensis of the panniculitis or the arthritis.
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