AI Article Synopsis
- Experiments in monkeys show that using the phosphodiesterase inhibitor phthalazinol can prevent chronic vasospasm and arterial injury caused by subarachnoid blood injection.
- This protective effect is effective even if the treatment starts after the blood is injected.
- The mechanism is thought to be related to phthalazinol's ability to inhibit platelets.
Article Abstract
Experiments in monkeys have demonstrated that the chronic vasospasm and arterial injury reaction produced by subarachnoid blood injection can be prevented by treatment with the phosphodiesterase inhibitor phthalazinol. This protective effect, which is present even when the drug treatment is initiated after the subarachnoid blood injection, is presumed to occur because of the platelet inhibiting effect of phthalazinol.
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| http://dx.doi.org/10.1161/01.str.10.6.638 | DOI Listing |
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