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Oral ulcers in children- a clinical narrative overview.
Ital J Pediatr
June 2021
University Children's Hospital of Basel, Spitalstrasse 33, 4056, Basel, Switzerland.
Article Synopsis
- - The occurrence of oral ulcers in children is about 9%, but diagnosing them can be tough because they are a symptom of various diseases.
- - Possible causes of oral ulcers include common childhood infections, nutritional deficiencies, gastrointestinal issues, inflammatory diseases, medication side effects, and chronic conditions.
- - A comprehensive review of literature identified 48 diseases associated with oral ulcers, leading to a guideline for clinicians to help diagnose and treat these conditions effectively.
Bleeding by Bruton Tyrosine Kinase-Inhibitors: Dependency on Drug Type and Disease.
Cancers (Basel)
March 2021
Institute for Cardiovascular Prevention, Ludwig-Maximilians University (LMU), 80336 Munich, Germany.
Bruton tyrosine kinase (Btk) is expressed in B-lymphocytes, myeloid cells and platelets, and Btk-inhibitors (BTKi) are used to treat patients with B-cell malignancies, developed against autoimmune diseases, have been proposed as novel antithrombotic drugs, and been tested in patients with severe COVID-19. However, mild bleeding is frequent in patients with B-cell malignancies treated with the irreversible BTKi ibrutinib and the recently approved 2nd generation BTKi acalabrutinib, zanubrutinib and tirabrutinib, and also in volunteers receiving in a phase-1 study the novel irreversible BTKi BI-705564. In contrast, no bleeding has been reported in clinical trials of other BTKi.
View Article and Find Full Text PDFMiscellaneous indications for extracorporeal photochemotherapy (ECP).
Transfus Apher Sci
June 2014
Head of Dijon Blood Transfusion Centre and Blood Collection Department, Etablissement Français du Sang Bourgogne Franche-Comté, site de Dijon, 2, rue Angélique Ducoudray, BP 47834, 21078 Dijon Cedex, France. Electronic address:
Extracorporeal photochemotherapy (ECP) has been applied to many T-cell mediated diseases where immunosuppressive drugs are insufficient or not tolerated. As ECP is mainly used in rare indications after failure of other therapies, controlled studies are hardly possible. In addition, the importance of the extracorporeal circuit imposes ethical doubts in organising sham ECP procedure, which explains the rarity of controlled double-blind studies.
View Article and Find Full Text PDFThe Dresden Apheresis Center - experience with LDL apheresis and immunoadsorption.
Atheroscler Suppl
December 2009
Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Fetscherstr. 74, 01307 Dresden, Germany.
The first apheresis center in former German Democratic Republic was established in Dresden November 1990 following the reunification of Germany. We here summarize the activities of this center to date. From the center's establishment until the end of July 2009 13,291 sessions of therapeutic apheresis have been performed.
View Article and Find Full Text PDFThe men behind the eponym: Francis E. Senear, Barney Usher, and the Senear-Usher syndrome.
Am J Dermatopathol
October 2003
Department of Dermatology, US Naval Hospital, Camp Pendleton, California, USA.
This historical review will summarize the report of Francis Senear and Barney Usher on a disease that they called pemphigus erythematodes and which later became pemphigus erythematosus (the Senear-Usher syndrome). It will then outline the lives of these two men. Finally, it will review the literature on that condition and relate the views of various authorities as to whether pemphigus erythematosus is merely pemphigus foliaceus, a variant of pemphigus foliaceus, a syndrome combining features of lupus erythematosus and pemphigus or whether pemphigus erythematosus (Senear-Usher syndrome) is a distinct and separate disease.
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