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Standardized Outcomes for Randomized Controlled Trials Targeting Early Interventions in Patients With Moderate-to-Severe Traumatic Brain Injury: Protocol for the Development of a Core Outcome Set.
JMIR Res Protoc
January 2025
INSERM, Methods in Patient-Centered Outcomes and Health Research, SPHERE, F-44000, Nantes Université, University of Tours, Nantes, France.
Background: : With more than 60 million new cases around the world each year, traumatic brain injury (TBI) causes substantial mortality and morbidity. Managing TBI is a major human, social, and economic concern. In the last 20 years, there has been an increase in clinical trials in neurocritical care, leading mostly to negative results.
View Article and Find Full Text PDFBackground: Vascular contributions to cognitive impairment and dementia (VCID) and Alzheimer's disease (AD) are the two most common forms of dementia, with overlapping risk factors including cardiovascular risk factors such as hypertension and dyslipidemia. The etiology of both VCID and AD shows sex-based differences, as well as sex-based differences in cardiovascular risk factors. However, how sex differences influence AD and angiogenic biomarkers in older adults who have high cardiovascular risk factors is not known.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Centre de recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, QC, Canada.
Background: Our objective was to assess individual and joint relationships between various mesoscale indicators of brain health (e.g., neuronal, metabolic, and vascular integrity) and cognitive function.
View Article and Find Full Text PDFPublic Health.
Alzheimers Dement
December 2024
Centre for Healthy Brain Ageing (CHeBA), University of New South Wales, UNSW Sydney, NSW, Australia.
Background: Social connections are linked to brain health. Studies to date have ignored negative social connections and the association between social connections and white matter health. We explored the relationship between positive and negative social connections and brain imaging including white matter health.
View Article and Find Full Text PDFPublic Health.
Alzheimers Dement
December 2024
Multi-Ethnic Health Equity Research Center, University of California, San Francisco, San Francisco, CA, USA.
Background: Prior studies suggest that neighborhood socioeconomic status, neighborhood walkability, and neighborhood social cohesion are associated with cognitive function and dementia risk. However, little is known about how neighborhood social and built environments influence dementia risk in South Asian populations residing in the US.
Methods: We used data from 745 South Asian individuals ≥40 years in the US who completed Exam 2 (2015-2018) of the Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study.
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