Protein transduction technology.

Curr Opin Biotechnol

Howard Hughes Medical Institute, Department of Cellular and Molecular Medicine, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0686, USA.

Published: February 2002

Intracellular delivery of macromolecules remains problematic because of the bioavailability restriction imposed by the cell membrane. Recent studies on protein transduction domains have circumvented this barrier, however, and have resulted in the delivery of peptides, full-length proteins, iron beads, liposomes, and radioactive isotopes into cells in culture and animal models in vivo.

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http://dx.doi.org/10.1016/s0958-1669(02)00284-7DOI Listing

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