Recent studies suggest that in addition to adipocytes the chief cells of the gastric fundic mucosa are a site of leptin production. In order to assess the possible role of vagal afferent neurons in transmitting leptin signals from the stomach to the brain, leptin receptor (OB-R) expression was investigated in rat nodose ganglion cells and their projection to the stomach determined by retrograde tracing. Reverse transcription-polymerase chain reaction combined with laser-assisted cell picking revealed that large and small diameter neurons express both the long (OB-Rb) and short (OB-Ra) splice variants of the OB-R. OB-R like immunoreactivity was detected in the perikarya of approximately 8% of nodose ganglion neurons. Tracing studies revealed that a significant proportion (15%) of the immunopositive neurons projected to the gastric fundus. These findings suggest that leptin may use a neural route to relay its message from peripheral sites of leptin synthesis such as the gastric fundus to the brain.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0304-3940(02)00023-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Adrenomedullin-mediated depressor response with visceral afferent-specific membrane depolarization in isolated nodose ganglion neurons from adult female rat.
Neuropeptides
December 2024
General Department, Wuxi Central Rehabilitation Hospital, The Affiliated Mental Health Center of Jiangnan University, Wuxi, 214151, China. Electronic address:
Article Synopsis
- Adrenomedullin (ADM) is a neuropeptide that regulates blood pressure and vasodilation, particularly in females, but its effect on baroreflex afferent function is not well understood.
- In a study with female rats, microinjection of ADM into the nodose ganglion led to a concentration-dependent reduction in blood pressure and varied responses in different neuron types, highlighting the differential effects on myelinated and unmyelinated neurons.
- The findings suggest that ADM plays a critical role in mediating baroreflex responses related to hypotension and vasodilation, emphasizing the importance of gender differences in these processes.
Noninvasive closed-loop acoustic brain-computer interface for seizure control.
Theranostics
September 2024
Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Article Synopsis
- The brain-computer interface (BCI) is crucial for advancing neuroscience and understanding brain functions, with non-invasive neuromodulation techniques playing a key role in innovations.
- Researchers developed a new non-invasive closed-loop acoustic BCI (aBCI) that uses electroencephalography (EEG) to detect seizures and employs ultrasound to stimulate the vagus nerve, effectively stopping seizures in a rat model.
- The aBCI selectively targets mechanosensitive neurons in the vagus nerve, shows significant effectiveness over conventional methods, and offers a promising and safe option for treating seizure disorders non-invasively.
Rat Sympathetic Neuron Calcium Channels Are Insensitive to Gabapentin.
Pharmaceuticals (Basel)
September 2024
Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA.
The gabapentenoids such as gabapentin (GP) and pregabalin are approved for the treatment of chronic pain, but their utility is limited by persistent side effects. These adverse effects result from GPs affecting many types of neurons and muscle cells, not just the pain-sensing neurons that are the intended targets. We have recently discovered a type of peripheral neuron, rat sympathetic neurons from the superior cervical ganglion (SCG), that is uniquely insensitive to GP effects.
View Article and Find Full Text PDFExpression of the cellular prion protein by mast cells in white-tailed deer carotid body, cervical lymph nodes and ganglia.
Prion
December 2024
Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Chronic wasting disease (CWD) is a transmissible and fatal prion disease that affects cervids. While both oral and nasal routes of exposure to prions cause disease, the spatial and temporal details of how prions enter the central nervous system (CNS) are unknown. Carotid bodies (CBs) are structures that are exposed to blood-borne prions and are densely innervated by nerves that are directly connected to brainstem nuclei, known to be early sites of prion neuroinvasion.
View Article and Find Full Text PDFFibroblast growth factor 8 promotes in vitro neurite outgrowth of placode-derived petrosal and nodose ganglia to varying degrees.
Ann Anat
October 2024
Institute of Anatomy, Neuroanatomy, Medical Faculty UKB, University of Bonn, Bonn, Germany. Electronic address:
Fibroblast growth factors (FGFs) are required for the specification and formation of the epibranchial placodes, which give rise to the distal part of the cranial sensory ganglia. However, it remains unclear whether FGFs play a role in regulating the neurite outgrowth of the epibranchial placode-derived ganglia during further development. Previous studies have shown that Fibroblast growth factor 8 (FGF8) promotes neurite outgrowth from the statoacoustic ganglion in vitro.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!