Evidence suggests that low serum enterolactone concentration might be an independent risk factor for acute coronary events. Enterolactone is a lignan, which is formed by intestinal bacteria from precursors in plant foods. Due to the biphenolic structure of enterolactone, it could act as an antioxidant and through this contribute to cardiovascular health. The aim of this study was to test the hypothesis that a low serum enterolactone concentration is associated with increased in vivo lipid peroxidation, assessed by plasma F2-isoprostane concentrations. We investigated this association in a subset of participants in 'The Antioxidant Supplementation in Atherosclerosis Prevention' (ASAP) study. Out of 256 male participants a subsample of 100 consecutive men from baseline was selected for F2-isoprostane assays. The mean serum enterolactone concentration was 16.6 nmol/l and that of F2-isoprostanes 29.6 ng/l. The correlation coefficient for association between serum enterolactone and F2-isoprostane concentrations was -0.30 (P<0.003). Plasma F2-isoprostane levels decreased linearly across quintiles of serum enterolactone concentration (P=0.008 for a linear trend). In a multivariate model, enterolactone persisted as a significant predictor after adjustment for vitamins and other variables, with the strongest associations with F2-isoprostanes. Our present data suggest that low serum enterolactone concentration is associated with enhanced in vivo lipid peroxidation in men.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0021-9150(01)00603-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Integrated Analysis of Serum and Tissue microRNA Transcriptome for Biomarker Discovery in Gastric Cancer.
Environ Toxicol
February 2025
Department of Gastroenterology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, China.
Article Synopsis
- Gastric cancer (GC) is a major global health issue, and research indicates that environmental pollutants may alter microRNA (miRNA) expressions, potentially playing a role in GC development.
- A comprehensive study analyzed the largest serum miRNA dataset, identifying 1766 differentially expressed miRNAs and revealing key regulators associated with clinical parameters and GC subtypes.
- Machine learning models showcased the diagnostic potential of specific miRNA profiles, highlighting miR-187 as a significant prognostic factor impacting patient survival and immune cell behavior in GC.
Effects of Flaxseed on Perimenopausal Symptoms: Findings From a Single-Blind, Randomized, Placebo-Controlled Study.
Cureus
September 2024
Clinical Biochemistry, Integral University Lucknow, Lucknow, IND.
Article Synopsis
- - This study investigates the effects of flaxseed supplementation on symptoms related to perimenopausal syndrome and blood levels of polyphenol metabolites in women, highlighting the hormonal benefits of flaxseed due to its phytoestrogens.
- - A total of 145 perimenopausal women participated, with one group receiving flaxseed powder and the other a placebo of roasted wheat flour over three months; various menopausal symptoms were assessed using specialized questionnaires.
- - Results showed significant improvements in menopausal symptoms for the flaxseed group, with substantial decreases in symptom scores and significant increases in beneficial blood metabolites, while the placebo group displayed minimal changes.
Association between polyphenol subclasses and prostate cancer: a systematic review and meta-analysis of observational studies.
Front Nutr
July 2024
Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China.
Background: The effect of polyphenol subclasses on prostate cancer (PCA) is controversial. Therefore, the purpose of this study was to investigate the relationship between polyphenol subclasses and PCA incidence.
Methods: From the establishment of the database to December 2023, a systematic search was conducted on PubMed, Web of Science, Embase, and Cochrane Library to identify relevant observational studies.
Secoisolariciresinol diglucoside attenuates neuroinflammation and cognitive impairment in female Alzheimer's disease mice via modulating gut microbiota metabolism and GPER/CREB/BDNF pathway.
J Neuroinflammation
August 2024
College of Food Science and Engineering, Northwest A&F University, Yangling, 712100, Shaanxi, China.
Background: Gender is a significant risk factor for late-onset Alzheimer's disease (AD), often attributed to the decline of estrogen. The plant estrogen secoisolariciresinol diglucoside (SDG) has demonstrated anti-inflammatory and neuroprotective effects. However, the protective effects and mechanisms of SDG in female AD remain unclear.
View Article and Find Full Text PDFFlaxseed Lignan Alleviates the Paracetamol-Induced Hepatotoxicity Associated with Regulation of Gut Microbiota and Serum Metabolome.
Nutrients
January 2024
Key Laboratory of Oilseeds Processing of Ministry of Agriculture and Rural Affairs, Hubei Key Laboratory of Lipid Chemistry and Nutrition, Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, No. 2 Xudong 2nd Road, Wuhan 430062, China.
This study examined the protective effect of flaxseed lignans on liver damage caused by an overdose of paracetamol (PAM). The findings demonstrated that administering 800 mg/kg/d flaxseed lignan prior to PAM significantly decreased the serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin (TBi) levels, while it increased liver superoxide dismutase (SOD) and glutathione (GSH) levels in mice. Flaxseed lignan renovated the gut microbiota dysbiosis induced by PAM by promoting the proliferation of sulfonolipid (SL) producing bacteria such as and lignan-deglycosolating bacteria such as while inhibiting the growth of opportunistic pathogen bacteria such as and .
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!