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Biomarkers.
Alzheimers Dement
December 2024
Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Background: Despite age being the primary risk factor for Alzheimer's disease (AD), there remains a necessity for a thorough understanding of the distinct biological pathways affected in the course of healthy aging as opposed to the pathological aging that leads to neurodegeneration. As the genome remains constant throughout one's lifespan, it becomes crucial to unravel the impact of aging on the proteome. Proteins, being key players in various cellular functions, mediate the effects of environmental stimuli and epigenetic alterations.
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Alzheimers Dement
December 2024
The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Background: Approximately 6.7 million people in the US are diagnosed with an Alzheimer's disease (AD), with greater incidence in women and minorities. Approximately 11 million family members provide uncompensated care to their family members with dementia, with more than 60% reporting high or very high levels of stress, a condition associated with increased risk for AD.
View Article and Find Full Text PDFBackground: Neuroinflammation and activation of the immune system can influence Alzheimer's disease (AD) progression. This is mediated by inflammatory molecules, which exacerbate the production of β-amyloid, the propagation of tau pathology, and neuronal loss. By measuring CSF markers of inflammation in a heterogeneous clinical cohort we found that levels of Adenosine Deaminase (ADA) and Matrix-Metaloproteinase-10 (MMP-10) increase in patients with AD.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Federal University of São Carlos, São Carlos, SP, Brazil.
Background: Blood-based biomarkers are gaining attention lately, and recent evidence supports the potential role of ADAM10 as an Alzheimer's disease (AD) biomarker. However, most available information on these biomarkers comes from high-income countries, where the population is usually highly educated. The influence of years of education (YoE) and older age on cognitive performance is well described in the literature, and they are risk factors for dementia.
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Alzheimers Dement
December 2024
Oregon Health & Science University, Portland, OR, USA.
Background: Alzheimer's disease (AD) is the fifth leading cause of death for individuals aged 65 and older. Since FDA approved therapies have limited efficacy, there is a need to develop new treatments based on a better understand of pathological changes occurring in tissues from humans with AD. Central nervous system cells utilize extracellular vesicles (EVs) to package and secrete miRNAs where they mediate cell-to-cell communication.
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