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Qualitative analysis of chemical constituents and study on the biological activity of L.
Nat Prod Res
November 2024
College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guizhou, China.
The chemical constituents of L. were qualitatively analysed by UPLC-MS/MS, and the biological activity of its ethanol extract was determined. 94 chemical constituents were identified, including 32 flavonoids, 5 phenylpropanoids, 6 phenols, 6 alkaloids, 13 fatty acyls, 6 organic acids, 12 amino acids and polypeptides, and 14 other classes.
View Article and Find Full Text PDF[Study on the difference and clinical value of serum amino acids in patients with laryngeal squamous cell carcinoma].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
August 2024
To detect the differences in types and levels of amino acids in the peripheral serum of patients with laryngeal squamous cell carcinoma and non-tumor patients, and explore their relationship with clinical parameters of laryngeal squamous cell carcinoma as well as their clinical value in diagnosis. High-performance liquid chromatography-tandem mass spectrometry（HPLC-MS） was employed to detect the serum amino acid contents and levels of 62 patients diagnosed with laryngeal carcinoma and 141 non-tumor patients at the First Affiliated Hospital of Jinzhou Medical University between September 2018 and February 2021. The study compared the differences in 22 non-essential and essential amino acids found in the serum between the experimental group and the control group.
View Article and Find Full Text PDFLipidomic, metabolomic, and behavior responses of zebrafish (Danio rerio) exposed to environmental levels of the beta blocker atenolol.
Sci Total Environ
March 2023
Center for Environmental and Human Toxicology, Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA; UF Genetics Institute, Interdisciplinary Program in Biomedical Sciences Neuroscience, University of Florida, USA. Electronic address:
Blood pressure medications are used to treat hypertension; however, low concentrations of beta-blockers in water systems can negatively impact aquatic wildlife. Here, we conducted a metabolic and behavioral study investigating atenolol, a beta-blocker frequently detected in global wastewater systems. The objectives were to determine the effects of low-level atenolol exposure on early stages of zebrafish.
View Article and Find Full Text PDFFunctional role of surface layer proteins of L-92 in stress tolerance and binding to host cell proteins.
Biosci Microbiota Food Health
September 2020
School of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama-shi, Kanagawa, Japan.
surface layer proteins (SLPs) self-assemble into a monolayer that is non-covalently bound to the outer surface of the cells. There they are in direct contact with the environment, environmental stressors and gut components of the host in which the organism resides. The role of SLPs is not entirely understood, although SLPs seem to be essential for bacterial growth.
View Article and Find Full Text PDFBiomarker of Aflatoxin Ingestion: ¹H NMR-Based Plasma Metabolomics of Dairy Cows Fed Aflatoxin B₁ with or without Sequestering Agents.
Toxins (Basel)
December 2018
Department of Animal Sciences, University of Florida, Gainesville, FL 32611, USA.
The study applied ¹H NMR-based plasma metabolomics to identify candidate biomarkers of aflatoxin B1 (AFB₁) ingestion in dairy cows fed no sequestering agents and evaluate the effect of supplementing clay and/or a fermentation product (SCFP) on such biomarkers. Eight lactating cows were randomly assigned to 1 of 4 treatments in a balanced 4 × 4 Latin square design with 2 squares. Treatments were: control, toxin (T; 1725 µg AFB₁/head/day), T with clay (CL; 200 g/head/day), and CL with SCFP (CL + SCFP; 35 g of SCFP/head/day).
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