Background: There is little information on using internal thoracic arteries (ITA) as free conduits in coronary artery bypass grafting. This study examines the results using both ITAs as free grafts in a lambda configuration implanting the common trunk into the ascending aorta.
Methods: Over a 6-year period, 317 patients underwent coronary artery revascularization with both ITAs as free grafts in a lambda configuration.
Results: An average of 4.9 distal anastomoses per patient was performed. There were 4 deaths (three early and one late). The mean NYHA class improved from preoperatively 2.8 to 1.1 at the last check. All 16 patients with suspected recurrent angina or a pathologic exercise test were restudied by angiography. Segmental graft stenosis or occlusion was found in 13 (in only one at aortic anastomosis). Five patients underwent late PTCA, and two underwent coronary reoperation. The six-year actuarial survival was 98% (90 % CL+/- 2 %), intervention-free survival 96 % (90 % CL +/- 2 %).
Conclusion: Revascularization using both ITAs as free grafts in a lambda configuration gives good early and mid-term results for up to 6 years. The aortic ITA anastomosis can be considered safe.
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http://dx.doi.org/10.1055/s-2002-20162 | DOI Listing |
Environ Sci Technol
December 2024
Stockholm University, Department of Environmental Science, SE-106 91 Stockholm, Sweden.
The class-wide restriction proposal on perfluoroalkyl and polyfluoroalkyl substances (PFAS) in the European Union is expected to affect a wide range of commercial sectors, including the lithium-ion battery (LIB) industry, where both polymeric and low molecular weight PFAS are used. The PFAS restriction dossiers currently state that there is weak evidence for viable alternatives to the use of PFAS in LIBs. In this Perspective, we summarize both the peer-reviewed literature and expert opinions from academia and industry to verify the legitimacy of the claims surrounding the lack of alternatives.
View Article and Find Full Text PDFFree Radic Biol Med
January 2025
Department of Pediatrics, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, 510655, China; Department of Pediatrics, Xinyi People's Hospital, Maoming, 525300, China. Electronic address:
Excessive autophagy has been implicated in the pathogenesis of necrotizing enterocolitis (NEC), yet the molecular underpinnings of the autophagy-lysosomal pathway (ALP) in NEC are not well characterized. This study aimed to elucidate alterations within the ALP in NEC by employing RNA sequencing on intestinal tissues obtained from affected infants. Concurrently, we established animal and cellular models of NEC to assess the therapeutic efficacy of itaconic acid (ITA).
View Article and Find Full Text PDFHeliyon
January 2024
Research Group Sylvanus, Institute for Technology Assessment and Systems Analysis (ITAS), Karlsruhe Institute of Technology, Karlstraße 11, 76133 Karlsruhe, Germany.
The leaf area of trees is the main surface of energy and matter exchange between the plant canopy and the atmosphere. A better understanding of canopy structure variations in cities is a prerequisite to evaluating leaf area and ecosystem services. We selected 58 single-standing and healthy Norway maple trees ( L.
View Article and Find Full Text PDFGen Thorac Cardiovasc Surg
October 2023
Department of Cardiovascular Surgery, Hanaoka Seishu Memorial Cardiovascular Clinic, Sapporo, Japan.
Purpose: There is controversy regarding which internal thoracic artery (ITA) should be anastomosed to the left anterior descending artery (LAD). Here, we propose an optimal graft design based on measurement of blood flow in the ITA.
Methods: Sixty-one patients (53 men, median age 68 [62-75] years) undergoing first elective coronary artery bypass grafting were enrolled.
Adv Med Educ Pract
September 2021
Centre for Medical Professional Development, Hunter New England Local Health District, Newcastle, NSW, Australia.
Introduction: Australia depends on international medical graduates (IMGs) to meet workforce shortages. The current standard assessment for IMGs is by clinical examination in observed structured clinical encounter (OSCE) format lasting 200 minutes. There are concerns about adequateness of this assessment as it does not test the qualities required to practice in a new country.
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