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Out of sight, into the spotlight: Beyond the current state of science on per- and poly-fluoroalkyl substances in groundwater.
J Environ Manage
January 2025
Department of Earth and Environmental Studies, Montclair State University, Montclair, NJ, 07043, USA.
Per- and poly-fluoroalkyl substances (PFAS) have emerged as a silent menace, infiltrating groundwater systems worldwide. Many countries, preoccupied with tackling legacy pollutants, have inadvertently neglected the emerging threat of PFAS. This review provides an exhaustive analysis beyond the current state of knowledge and sustainable pathways vis-a-vis addressing PFAS in groundwater systems globally.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Background: The Genome Center for Alzheimer's Disease (GCAD) coordinates the integration and meta-analysis of all available Alzheimer's disease (AD) relevant whole genome sequencing (WGS) data to facilitate the goal of identifying AD risk or protective genetic variants and eventual therapeutic targets. The WGS datasets are generated via the collaboration of scientists from the Alzheimer's Disease Sequencing Project (ADSP) and GCAD. To minimize data heterogeneity introduced by different sequencing protocols and machines, GCAD processes all samples using identical pipelines.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
University of Pittsburgh, Pittsburgh, PA, USA.
Background: Gaining insight into the emotional consequences of disclosing amyloid Positron Emission Tomography (PET) results is essential for offering effective support to patients of varying cognitive status. This analysis aimed to examine variations in emotional distress levels following the disclosure of amyloid PET results among participants that are cognitively normal, with Mild Cognitive Impairment (MCI), or dementia.
Method: This investigation was a preliminary analysis of 55 participants, using 1-month follow-up call data of an ongoing brain imaging data repository study, obtaining baseline PET imaging on a subset of Alzheimer's Disease Research Center (ADRC) participants.
CDC40 suppression induces CDCA5 splicing defects and anti-proliferative effects in lung cancer cells.
Sci Rep
January 2025
Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, M5G 0A3, Canada.
High mortality and low response rates in lung cancer patients call for novel therapeutic targets. Data mining of whole-genome genetic dependency screens suggest Cell Division Cycle 40 (CDC40) to be an essential protein for lung cancer cell survival. We characterized CDC40 knockdown effects in multiple lung cancer cell lines, revealing induced cell cycle defects that resulted in strong growth inhibition and activation of apoptosis.
View Article and Find Full Text PDFStreamlining Global Germplasm Exchange: Integrating Scientific Rigor and Common Sense to Exclude Phantom Agents from Regulation.
Plant Dis
December 2024
Department of Plant Protection, Biotechnical Faculty, University of Montenegro, 81000 Podgorica, Montenegro.
Article Synopsis
- A team of over 180 researchers from more than 40 countries is addressing the issues related to "phantom agents," which are proposed pathogenic agents that are listed without concrete evidence of their existence.
- These phantom agents, identified only through symptoms and lacking proper isolates or genetic data, create obstacles for trade and plant certification, making effective detection and risk assessment difficult.
- The researchers recommend removing these agents from regulatory lists and updating standards in line with modern diagnostic methods to facilitate germplasm exchange and support global agriculture.
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