K channels are ubiquitous in animal cells, where they are involved in a variety of physiological functions. In epithelial cells of the kidney, K channels are primarily involved in maintaining membrane potential, recycling and secreting K and regulating cell volume. As many renal K channels have now been studied or identified at the molecular level by means of a variety of approaches, including patch-clamp recordings, cDNA cloning and immunohistochemistry, the purpose of this review is to summarize what is presently known about the molecular identity of renal K channels with an emphasis on their regulatory properties.
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