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Exploration and Enrichment Analysis of the QTLome for Important Traits in Livestock Species.
Genes (Basel)
November 2024
Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico.
Quantitative trait loci (QTL) are genomic regions that influence essential traits in livestock. Understanding QTL distribution and density across species' genomes is crucial for animal genetics research. This study explored the QTLome of cattle, pigs, sheep, and chickens by analyzing QTL distribution and evaluating the correlation between QTL, gene density, and chromosome size with the aim to identify QTL-enriched genomic regions.
View Article and Find Full Text PDFDipeptidyl peptidase 4 is a cofactor for porcine epidemic diarrhea virus infection.
Vet Microbiol
January 2025
College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China. Electronic address:
Article Synopsis
- Porcine epidemic diarrhea virus (PEDV) is extremely deadly for neonatal piglets, with a mortality rate that can reach 100%, causing significant economic losses in the pig industry.
- The study identifies dipeptidyl peptidase 4 (DPP4) as a cofactor that enhances PEDV invasion and replication by mapping its expression in various piglet tissues and showing its distribution in intestinal cells.
- Research indicates that inhibiting DPP4 reduces PEDV infection, and experiments suggest that DPP4 and PEDV interact directly, reinforcing the idea that DPP4 plays a crucial role in the virus’s ability to infect pigs.
The effects of runs-of-homozygosity on pig domestication and breeding.
BMC Genomics
January 2025
Key Laboratory of Genetic Evolution & Animal Models and Yunnan Key Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.
Background: Since their domestication, recent inbreeding together with intensive artificial selection and population bottlenecks have allowed the prevalence of deleterious mutations and the increase of runs-of-homozygosity (ROH) in domestic pigs. This makes pigs a good model to understand the genetic underpinnings of inbreeding depression.
Results: Here we integrated a comprehensive dataset comprising 7239 domesticated pigs and wild boars genotyped by single nucleotide polymorphism (SNP) chips, along with phenotypic data encompassing growth, reproduction and disease-associated traits.
Preclinical Experience Using 4D Intracardiac Echocardiography to Guide Cardiac Electrophysiology Procedures.
J Cardiovasc Electrophysiol
December 2024
Division of Cardiovascular Medicine, Cardiac Electrophysiology Section, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Introduction: Intracardiac echocardiography (ICE) is an essential imaging modality for electrophysiology procedures, allowing intraprocedural monitoring, real-time catheter manipulation guidance, and visualization of complex anatomic structures. Four-dimentional (4D) ICE is the next stage in the evolution of the technology, permitting 360° rotation of the imaging plane, simultaneous multiplanar imaging, and volumetric acquisition, similar to transesophageal echocardiography (TEE). In this study, we report our experience with a novel 4D ICE catheter (NuVision, Biosense Webster) in structural electrophysiology procedures and difficult ventricular ablations in a swine preclinical model.
View Article and Find Full Text PDFValidation of the effectiveness of pig farm repopulation protocol following African swine fever outbreaks in the Philippines.
Front Vet Sci
December 2024
Center for Animal Health and Food Safety, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN, United States.
The African swine fever (ASF) epidemic has severely challenged the Philippines' swine industry since 2019. The National African Swine Fever Prevention and Control Program (NASFPCP), launched in 2021, aims to provide guidance for managing ASF through surveillance, monitoring, and swine repopulation. This study evaluates the effectiveness of post-outbreak disinfection protocols and government-mandated measures for repopulation standard.
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