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Intra-articular Synovial Ganglion of the Wrist.
J Hand Surg Glob Online
November 2024
Traumatólogo Equipo de Mano, Clínica Universidad de los Andes, Santiago, Chile.
Synovial ganglions, common soft tissue tumors of the hand and wrist, typically occur in the dorsal and volar aspects of the wrist, but intra-articular cases are rare. We present a case of a 27-year-old equestrian with persistent left wrist pain who was diagnosed with an intra-articular radiocarpal synovial ganglion after failed conservative management. Arthroscopic resection led to complete resolution of symptoms and functional recovery.
View Article and Find Full Text PDFSpecialized pro-resolving mediator Maresin 1 attenuates pain in a mouse model of osteoarthritis.
Osteoarthritis Cartilage
November 2024
Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC 27710, USA; Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27710, USA; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA. Electronic address:
Objective: We test whether the specialized pro-resolving molecule Maresin 1 (MaR1) attenuates nociceptive behaviors in mice with osteoarthritis-like pain.
Design: Osteoarthritis (OA)-like pain behavior was induced by intra-articular injection of monosodium iodoacetate (MIA) and treated with MaR1 (N=6) or vehicle (N=5) by intraperitoneal injection 8 weeks after injury. Mice without MIA injection were used as control (N=6).
Direct Effects of the Janus Kinase Inhibitor Baricitinib on Sensory Neurons.
Int J Mol Sci
November 2024
Institute of Physiology 1/Neurophysiology, Jena University Hospital, Friedrich-Schiller-University, D-07740 Jena, Germany.
Article Synopsis
- Baricitinib, a Janus kinase inhibitor, helps alleviate rheumatoid arthritis symptoms and pain by affecting joint nociceptors.
- In studies with rats, baricitinib did not impact normal joint responses but reduced pain signals from inflamed joints, particularly in C-fibers.
- The drug works by blocking the activation of Stat3, a signaling pathway involved in pain sensitivity, suggesting that it directly influences pain mechanisms in inflamed conditions.
Comparison of effects of intra-articular diclofenac etalhyaluronate and hyaluronic acid in a monoiodoacetate rat osteoarthritis model.
J Orthop Res
November 2024
Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Chuo-ku, Japan.
Diclofenac etalhyaluronate (DF-HA) sustained diclofenac release with the effects of hyaluronic acid (HA), offering long-term analgesia in osteoarthritis. In this study, the effects of DF-HA on pain improvement and osteoarthritis were evaluated in a rat knee monoiodoacetate-induced osteoarthritis model compared to HA. Eight rats per group had been injected with monoiodoacetate (2.
View Article and Find Full Text PDFArticle Synopsis
- Family physicians can effectively provide injections for wrist pain when initial treatments like NSAIDs and rest don't work.
- While corticosteroid injections may offer relief, they come with risks such as infection and cartilage damage that should be discussed.
- Various techniques like ultrasound-guided injections have shown better results for conditions like carpal tunnel syndrome, while treatment for other wrist issues includes options like rest, therapy, and in some cases, corticosteroid injections.
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