In this article, human semen analysis is examined critically and some of the difficulties it presents in terms of interpretation are highlighted. The problem of defining fertility is raised and a brief comparison is made between farm animals and humans. The purpose of analysis in each differs markedly, yet conventional tests on human semen are derived from semen analysis in animals. Sperm count, sperm motility and sperm morphology are considered and the point is made that in attempts to predict the fertilizing capacity of a semen sample, measurement of the volume of the semen is unhelpful. It is also stressed that several different tests must be applied for a meaningful report to be produced. It is suggested that different boundaries from those applied in animals are required in humans. This is because there is much greater variation in the quality of human semen than in that of animals and, therefore, in trying to establish a norm, a broader framework is required. Finally, it is proposed that fundamental research into the physiology of human spermatozoa is necessary to achieve better standards in semen testing in the future.
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http://dx.doi.org/10.1080/1464727992000198291 | DOI Listing |
Background: An estimated 17% of all couples worldwide are involuntarily childless (infertile). The clinically identifiable causes of infertility can be found in the male or female partner or in both. The molecular pathophysiology of infertility still remains unclear in many cases but is increasingly being revealed by genetic analyses.
View Article and Find Full Text PDFJBRA Assist Reprod
January 2025
Molecular Medicine, Nutrigenomics and Public Health Research Laboratory, Department of Bio-Medical Laboratory Science and Management, Vidyasagar University, Midnapore 721 102, West Bengal, India.
Objective: The study focused the contraceptive efficacy of hydro-ethanolic (60:40) extract (HEE) of Caesalpinia pulcherrima leaves in human and rat sperm samples by in vitro study.
Methods: Six young fertile adult males were selected for semen collection. Sperm samples were collected from six adult rat also by chopping the epididymis along with the collection of testicles, epididymis, and liver.
Acta Obstet Gynecol Scand
January 2025
Department of Biomedical Sciences, Humanitas University, Milan, Italy.
Introduction: Recurrent pregnancy loss (RPL), defined as two or more consecutive pregnancy losses before 24 weeks of gestation, affects up to 1%-2% of couples. Aim of this retrospective cohort study was to report the main causes and pregnancy outcomes of a cohort of women with RPL and the efficacy of a personalized work-up and treatment in terms of live birth rate.
Material And Methods: Women with primary (pRPL) and secondary (sRPL) RPL underwent a complete work-up and personalized therapeutic management.
Am J Reprod Immunol
January 2025
Laboratory of Molecular Genetics and Experimentation in Animal Reproduction, University of Western São Paulo (Unoeste), Presidente Prudente, São Paulo, Brazil.
Problem: A high-fat diet (HFD) predisposes animals to glucose intolerance, dyslipidemia and testicular oxidative stress, and impairs sperm production in rats. Quercetin is a flavonoid with antioxidant, anti-inflammatory, and lipolytic actions and is a potential supplement to combat the oxidative stress caused by HFD and its harmful effects on reproduction. This study evaluated the effects of quercetin supplementation at doses of 10 and 20 mg/day on reproductive parameters and testicular oxidative stress in Wistar rats fed a diet rich in pork fat and fructose.
View Article and Find Full Text PDFBackground: There has been growing interest to study impact of night shift work on male reproductive health, which is regulated by the hypothalamic-pituitary-gonadal axis and influenced by circadian rhythms. This systematic review and meta-analysis aim to explore the association between night shift work and male reproductive health outcomes.
Methods: This systematic review and meta-analysis followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines (PROSPERO: CRD42022379770).
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