Urachal carcinoma is a rare neoplasm with the majority of cases reported in the urologic literature. Because of its presentation as an intra-abdominal mass with involvement of adjacent structures the general surgeon may be consulted early in the diagnostic evaluation. One should be aware of this entity as early recognition and appropriate surgery provides the best opportunity for long-term survival. Herein we describe a typical case, appropriate evaluation, and review of the literature.
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[SUCCESSFUL TREATMENT WITH mFOLFOX6 FOR URACHAL ADENOCARCINOMA WITH MULTIPLE LUNG METASTASIS: A CASE REPORT].
Nihon Hinyokika Gakkai Zasshi
January 2025
Department of Urology, Yokohama Municipal Citizen's Hospital.
We report the case of a 41-year-old man who presented with gross hematuria and a bladder tumor on ultrasonography. Magnetic resonance imaging indicated a possible muscle-invasive bladder cancer or urachal carcinoma. Following transurethral resection of the bladder tumor, histopathological findings revealed an adenocarcinoma similar to colorectal cancer.
View Article and Find Full Text PDFComprehensive analysis of targetable mutations and tumor microenvironment in urachal cancer.
NPJ Precis Oncol
January 2025
University of California, Irvine, Orange, CA, 92868, USA.
Urachal cancer, a rare malignancy, generally presents in the clinical setting with advanced stages of disease. Systemic treatment with chemotherapy is generally utilized in this setting. However, there remains a paucity of data on the effectiveness of immune checkpoint inhibitors or targeted therapies for urachal cancer.
View Article and Find Full Text PDFPrecision Oncology Approach for Urachal Carcinoma: A Clinical Case Report.
Int J Mol Sci
December 2024
Department of Urology, Semmelweis University, Üllői Street 78/b, H-1082 Budapest, Hungary.
Urachal cancer (UrC) is a rare disease which is mostly diagnosed late due to symptoms caused by its local invasion to the urinary bladder. Given the lack of clinical trials and guideline recommendations for systemic treatment, a molecularly informed precision oncology approach is a viable option for UrC already in the early lines of systemic treatment. While single case experiences may provide valuable reference for later decision-making, well-documented clinical experience with off-label targeted treatments is limited to a few patients.
View Article and Find Full Text PDFArticle Synopsis
- The urachus is a leftover structure from fetal development that connects the bladder to the belly button, and cancers arising from it, known as primary urachal carcinoma, are rare but aggressive.
- A case study presents a 48-year-old woman with abdominal pain and a mass, which was diagnosed as squamous cell carcinoma after imaging and biopsy.
- Treatment typically involves surgery to remove the tumor and surrounding tissue to reduce the chance of spreading, but guidelines are sparse due to the rarity of this type of cancer, with current protocols based on limited data.
Invasive mucinous urachal adenocarcinoma: A case report of surgical management and insights from the literature.
Int J Surg Case Rep
December 2024
Faculty of Medicine, Polytechnic University of Palestine, Hebron, Palestine; Department of Urology, Governmental Hebron Hospital, Palestine.
Introduction And Importance: Urachal carcinoma (UrC) is a rare bladder malignancy originating from the urachus. Comprising around 90 % adenocarcinomas, most cases are invasive. Urachal adenocarcinoma is less common than its non-urachal counterpart and is recognized for its aggressive nature, often diagnosed at advanced stages with a poor prognosis.
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