The synthesis of 2-(2,2-bis(4-chlorophenyl)ethyl]-2-(4-chlorophenyl)-thiazolidin-4-one (3) from p,p'-dichlorochalcone (1) via 1,3,3-tris(4-chlorophenyl)-propan-1-one (2) using thioglycollic acid in the presence of ammonium carbonate is described. Structural assignment, stereochemistry and biological assay are discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0223-5234(01)01268-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Continuous Production of Bifunctional Platform Chemicals from Plant Oils in Water by Cyclodextrin-Mediated Hydroformylation.
ChemSusChem
January 2025
TU Dortmund University: Technische Universitat Dortmund, Biochemical and Chemical Engineering, Emil-Figge-Straße 66, 44227, Dortmund, GERMANY.
Platform chemicals from renewable resources with broad applications are highly desirable, particularly for replacing fossil-based monomers. Bifunctional aliphatic ester-aldehydes, accessible via regioselective hydroformylation of unsaturated oleochemicals, can be converted into linear ω-amino/ω-hydroxy esters and dicarboxylic acids-key building blocks for biobased aliphatic polycondensates. However, their success hinges on efficient, economically viable production, with catalyst recycling being critical.
View Article and Find Full Text PDFDecoding Dual-Functionality in N-doped Defective Carbon: Unveiling Active Sites for Bifunctional Oxygen Electrocatalysis.
Small
January 2025
Institute of Nano Science and Technology, Sector-81, Knowledge city, S.A.S. Nagar, Punjab, 140306, India.
Oxygen electrocatalysis plays a pivotal role in energy conversion and storage technologies. The precise identification of active sites for oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) is crucial for developing an efficient bifunctional electrocatalyst. However, this remains a challenging endeavor.
View Article and Find Full Text PDFDipicolylamine Derivatives Bearing Pyrene and Anthracene as Molecular Probes for Cu and HS.
J Fluoresc
January 2025
Guangxi Key Laboratory of Electrochemical Energy Materials, School of Chemistry and Chemical Engineering, Guangxi University, No. 100, Daxue East Road, Nanning, Guangxi, 530004, China.
Two dipicolylamine (DPA) derivatives with the pyrene and anthracene groups, 1-(pyren-1-yl)-N, N-bis-(pyridine-2-ylmethyl)benzylamine (L1) and 1-(anthracen-9-yl)-N, N-bis-(pyridine-2-ylmethyl)benzylamine (L2) were synthesized, characterized, and their affinitive properties for metal ions were studied. The mass spectroscopy and Job's plots showed that L1 and L2 reacted with Cu and formed complexes [Cu(L1)(solvent)] (L1-Cu) and [Cu(L2)(solvent)] (L2-Cu), respectively. Both L1 and L2 were fluorescent probes recognizing Cu via the emission quenching and further detecting HS via the emission revival.
View Article and Find Full Text PDFChemodivergent dearomatization of benzene-linked O-oxime esters EnT-induced radical cross-coupling.
Chem Sci
January 2025
Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology (SCUT) Guangzhou 510640 China.
Radical-mediated dearomatization strategies offer a blueprint for building value-added and synthetically valuable three-dimensional skeletons from readily available aromatic starting materials. Herein, we report a novel strategy by leveraging benzene-linked O-oxime esters as triply functionalized precursors to form two distinct persistent radicals under a chemodivergent pathway. These radicals then couple with a cyclohexadienyl radical for either carboamination or carbo-aminoalkylation.
View Article and Find Full Text PDFBis-3-chloropiperidines: a novel motif for anthelmintic drug design.
RSC Adv
January 2025
Institute of Organic Chemistry, Justus Liebig University 35392 Giessen Germany https://www.uni-giessen.de/de/fbz/fb08/Inst/organische-chemie/AGGoettlich.
Parasites account for huge economic losses by infecting agriculturally important plants and animals. Furthermore, morbidity and death caused by parasites affect a large part of the world population, especially in economically weak regions. Anthelmintic drugs to tackle this challenge remain scarce and their efficiency becomes increasingly endangered by the advent of drug resistance development.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!