AI Article Synopsis
- In myeloid leukemia, immature leukemic cells can migrate into the bloodstream and invade other organs, prompting a study of HL-60 and NB4 cell lines that represent acute myelogenous leukemia.
- Granulocytic differentiation induced by agents like ATRA and ACLA significantly enhanced the migration and invasion of these cells, affecting the levels of MMP-9 and uPA in different ways.
- The findings suggest that these agents modulate the expression of MMPs and protease inhibitors, indicating potential clinical implications for treating complications like ATRA syndrome.
Article Abstract
In myeloid leukemia, immature leukemic cells are able to egress into peripheral blood to infiltrate extra-medullary organs. We therefore analyzed the migrating and invasive potential of human HL-60 and NB4 cell lines, representative of acute myelogenous leukemia, their ability to express matrix metalloproteases (MMPs), tissue inhibitors of metalloproteases (TIMPs) and urokinase plasminogen activator (uPA) in response to differentiating agents. Granulocytic differentiation by all-trans-retinoic acid (ATRA) and aclacinomycin (ACLA) strongly increased HL-60 and NB4 cell migration and invasion. At mRNA and protein levels, these cell lines produced significant amounts of MMP-9 (HL-60
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http://dx.doi.org/10.1016/s0006-2952(01)00848-6 DOI Listing Publication Analysis
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