Objective: Nucare, a short-term psychoeducational coping skills training intervention was evaluated in a randomized controlled clinical trial (RCT) of 225 newly diagnosed breast and colon cancer patients.
Method: Measures of psychosocial distress, well being and optimism were evaluated every four months during a one-year period. Patients were randomized to one of four arms: Nucare presented in an individual basis; Nucare presented in a group format; a non-directive supportive group; and a no-intervention control. The interventions were provided in five sessions of ninety minutes each.
Results: Patients with breast cancer who received Nucare presented in an individual format showed more significant improvements in well-being over time compared to those in the control and group arms.
Conclusions: We were unable to develop functioning groups within the RCT. Partial explanations for the latter finding include the structural limitations of the RCT: the groups were small, difficult to schedule and patients indicated that they would have preferred to choose whether or not to participate in a group. The positive changes in women with breast cancer who received Nucare persisted at 12 months.
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http://dx.doi.org/10.2190/U0P3-5VPV-YXKF-GRG1 | DOI Listing |
Drug Deliv Transl Res
June 2024
NGSM Institute of Pharmaceutical Sciences, Department of Pharmaceutics,, NITTE Deemed-to-be University, Mangalore, 575018, India.
Parkinson's disease (PD), affecting millions of people worldwide and expected to impact 10 million by 2030, manifests a spectrum of motor and non-motor symptoms linked to the decline of dopaminergic neurons. Current therapies manage PD symptoms but lack efficacy in slowing disease progression, emphasizing the urgency for more effective treatments. Resveratrol (RSV), recognized for its neuroprotective and antioxidative properties, encounters challenges in clinical use for PD due to limited bioavailability.
View Article and Find Full Text PDFCancer Immunol Immunother
April 2024
Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Braz J Biol
March 2024
Nitte (Deemed to be University), NGSM Institute of Pharmaceutical Sciences - NGSMIPS, Department of Nitte University Centre for Animal Research and Experimentation - NUCARE, Paneer campus, Deralakatte, Mangaluru, India.
Arthralgex is a proprietary polyherbal preparation used in clinics to treat rheumatoid arthritis for decades. Its safety evaluation has not been reported. The study is aimed at evaluating the safety of arthralgex using Wistar rats, as per OECD guidelines.
View Article and Find Full Text PDFJ Pharmacol Toxicol Methods
January 2023
Nitte (Deemed to be University), NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Department of Nitte University Centre for Animal Research and Experimentation (NUCARE), Paneer campus, Deralakatte, Mangaluru 575 018, Karnataka, India. Electronic address:
Protein malnutrition continues to be a major global issue. A stable animal model to address protein malnutrition and its effect on various disease conditions is necessary. In the present study, we have formulated and standardized a low protein diet (LPD) to develop a protein malnutrition model using Balb/C mice.
View Article and Find Full Text PDFJ Basic Clin Physiol Pharmacol
February 2021
Department of Pharmacology, NGSM Institute of Pharmaceutical Sciences, Mangalore, India.
Objectives: Psoriasis is an autoimmune, inflammatory disease that needs a reliable animal model. Imiquimod (IMQ)-induced psoriasis is a widely used preclinical tool for psoriasis research. However, this model is sensitive to the genetic variation of mice.
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