Gynaecomastia is the commonest benign condition of the male breast. Management consists primarily of taking a complete history and making a thorough clinical examination. Ultrasound is recommended as the first-line imaging investigation although mammography may be added to confirm the diagnosis. The results of fine-needle aspiration cytology may be poor as an adequate yield of pathological specimens is low, and it should be reserved for suspected malignant lesions. Endocrine evaluation of gynaecomastia is rarely productive and such testing is best done selectively. Many patients can be treated simply with reassurance about the benign nature of the condition. In those patients in whom a stimulus has been identified modification of treatment may improve symptoms. Hormonal manipulation may be appropriate in younger patients, but a testicular neoplasm must be excluded. Operations should be reserved for those who fail to respond to hormones and in those with severe cosmetic deformities.
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http://dx.doi.org/10.1080/110241501753361550 | DOI Listing |
Ann Pediatr Endocrinol Metab
January 2025
The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Clin Endocrinol (Oxf)
January 2025
Department of Paediatric Endocrinology, Alder Hey Children's Hospital, Liverpool, UK.
Background: Klinefelter syndrome (KS) is an uncommonly recognised condition typified by gynaecomastia, small testes and aspermatogenesis. It is caused by a supernumerary X chromosome, resulting in a 47 XXY karyotype. Since its first description, the phenotype of KS has evolved and there is a much greater appreciation of the subtle features of the condition.
View Article and Find Full Text PDFJ Small Anim Pract
January 2025
Department of Veterinary Medicine and Surgery, University of Missouri, College of Veterinary Medicine, Columbia, Missouri, USA.
A 9-year-old, presumed male castrated mixed breed dog was evaluated for lethargy, hyporexia, polyuria, polydipsia and diffuse gynaecomastia. Bloodwork revealed severe hypercalcaemia and hyposthenuria. CT scan showed a caudal abdominal mass consistent with a Sertoli cell tumour on cytology.
View Article and Find Full Text PDFJ Clin Med
December 2024
Department of Aesthetic and Reconstructive Breast Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100144, China.
Pubertal gynecomastia (PG) is a common condition characterized by the abnormal development and hyperplasia of unilateral or bilateral breast tissue in adolescent males, affecting up to 50% of appropriately aged adolescents and exhibiting rising prevalence over recent years. The etiology of PG is multifaceted, encompassing physiological, pharmacological, and pathological factors. This narrative review synthesizes evidence from a comprehensive selection of peer-reviewed literature, including observational studies, clinical trials, systematic reviews, and case reports, to explore the pivotal role of endocrine hormones in the pathogenesis of PG.
View Article and Find Full Text PDFClin Kidney J
January 2025
Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
The mineralocorticoid receptor (MR) is a nuclear transcription factor that plays a critical role in regulating fluid, electrolytes, blood pressure, and hemodynamic stability. In conditions such as chronic kidney disease (CKD) and heart failure (HF), MR overactivation leads to increased salt and water retention, inflammatory and fibrotic gene expression, and organ injury. The MR is essential for transcriptional regulation and is implicated in metabolic, proinflammatory, and pro-fibrotic pathways.
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