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Staged hybrid approach for acute type A aortic dissection: zone 2 arch replacement and completion thoracic endovascular aortic repair upon indication.
Eur J Cardiothorac Surg
March 2025
Department of Cardiothoracic Surgery, Radboud University Medical Center, Nijmegen, Netherlands.
Objectives: This study evaluates a staged selective hybrid approach for acute type A aortic dissection. The approach involves a zone 2 aortic arch replacement with debranching of the brachiocephalic trunk and left common carotid artery to create a landing zone for thoracic endovascular aortic repair. This repair is performed either preemptively in the subacute phase to promote remodelling or electively in the chronic phase to manage aneurysm formation.
View Article and Find Full Text PDFAutophagy and Programmed Cell Death Modalities Interplay in HIV Pathogenesis.
Cells
February 2025
Departmental Faculty of Medicine, Saint Camillus International University of Health Sciences, 00131 Rome, Italy.
Human immunodeficiency virus (HIV) infection continues to be a major global health challenge, affecting 38.4 million according to the Joint United Nations Program on HIV/AIDS (UNAIDS) at the end of 2021 with 1.5 million new infections.
View Article and Find Full Text PDFNavigating Diagnostic Uncertainty: A Neck Swelling in an Elderly Patient Prompting Reflection on Over-investigation.
Indian J Otolaryngol Head Neck Surg
January 2025
Department of Otorhinolaryngology, St Johns Medical College, Bangalore, Karnataka 560034 India.
A brief communication report highlighting a 69-year-old male with a history of chronic conditions who presented with a persistent neck swelling following an upper respiratory tract infection. Despite multiple benign findings from various diagnostic procedures, the patient's anxiety about a potential malignancy led to repeated investigations, culminating in a left-sided neck dissection. The case underscores the challenges of managing patient-driven demands for certainty in an era of defensive medicine, where physicians may feel compelled to order excessive tests.
View Article and Find Full Text PDFDonor Lymphocyte Infusion (DLI) is a crucial therapeutic strategy for relapsed myeloid malignancies post-allogeneic hematopoietic cell transplantation (allo-HCT), leveraging the graft-versus-leukemia (GvL) effect to restore immune control. While highly effective in chronic myeloid leukemia (CML), its efficacy in acute myeloid leukemia (AML) remains limited, with underlying mechanisms not fully understood. Recent research by Maurer and colleagues utilized cutting-edge technologies to dissect immune-leukemia interactions within the bone marrow niche, identifying a cytotoxic CD8+ T cell population as a key mediator of the anti-leukemic response.
View Article and Find Full Text PDFAortic Dissection: An Unexpected Complication of Transcatheter Aortic Valve Implantation.
Cureus
February 2025
Cardiology, Unidade Local de Saúde (ULS) São João, Porto, PRT.
A 53-year-old female with a medical history of multiple cardiovascular risk factors, alcoholic chronic hepatic disease (Child-Pugh B) with thrombocytopenia, and severe calcified aortic stenosis was admitted for an elective transcatheter aortic valve implantation (TAVI). After the procedure, the patient was hypotensive and unresponsive to fluid challenge, and there was a significant difference in blood pressure between the two arms. The echocardiogram confirmed the normal position and function of the prosthetic valve but was suggestive of aortic dissection.
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