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Recent studies indicate that the development of drug resistance and increased invasiveness in melanoma is largely driven by transcriptional plasticity rather than canonical coding mutations. Understanding the mechanisms behind cell identity shifts in oncogenic transformation and cancer progression is crucial for advancing our understanding of melanoma and other aggressive cancers. While distinct melanoma phenotypic states have been well characterized, the processes and transcriptional controls that enable cells to shift between these states remain largely unknown.
View Article and Find Full Text PDFProstate cancer (PC) progresses from benign epithelium through pre-malignant lesions, localized tumors, metastatic dissemination, and castration-resistant stages, with some cases exhibiting phenotype plasticity under therapeutic pressure. However, high-resolution insights into how cell phenotypes evolve across successive stages of PC remain limited. Here, we present the Prostate Cancer Cell Atlas (PCCAT) by integrating ∼710,000 single cells from 197 human samples covering a spectrum of tumor stages.
View Article and Find Full Text PDFProperties of New Partially Crystallized Lithium Disilicate CAD-CAM Materials.
Oper Dent
January 2025
*Kraig S. Vandewalle, DDS, MS, Col (ret), USAF, DC, Air Force Consultant in Dental Research Advanced Education in General Dentistry Residency, AF Postgraduate Dental School, Joint Base San Antonio - Lackland, TX, USA; Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Objective: The purpose of this study was to compare the optical, mechanical, and biological properties of two new, inexpensive lithium disilicate (LS2) materials (Lodden (LOD), LD Medical Technology; and BeautyZir (BZ), BeautyZir Technology) to a clinically established LS2 material (IPS e.max CAD (EMAX), Ivoclar Vivadent).
Methods And Materials: The optical properties of the translucency parameter (TP) and opalescence parameter (OP) were obtained with a dental spectrophotometer.
Multimodal transcriptomics reveal neurogenic aging trajectories and age-related regional inflammation in the dentate gyrus.
Nat Neurosci
January 2025
Laboratory of Neural Plasticity, Faculties of Medicine and Science, Brain Research Institute, University of Zurich, Zurich, Switzerland.
The mammalian dentate gyrus (DG) is involved in certain forms of learning and memory, and DG dysfunction has been implicated in age-related diseases. Although neurogenic potential is maintained throughout life in the DG as neural stem cells (NSCs) continue to generate new neurons, neurogenesis decreases with advancing age, with implications for age-related cognitive decline and disease. In this study, we used single-cell RNA sequencing to characterize transcriptomic signatures of neurogenic cells and their surrounding DG niche, identifying molecular changes associated with neurogenic aging from the activation of quiescent NSCs to the maturation of fate-committed progeny.
View Article and Find Full Text PDFAnatomical-Based Filler Injection Techniques: Anteromedial, Buccal, and Lateral Cheek Hollow.
Aesthetic Plast Surg
January 2025
Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.
Background: Hollowness in the anteromedial, buccal, and lateral cheek regions is a common concern in aesthetic medicine, often resulting from age-related volume loss and structural changes. Advanced filler injection techniques that incorporate a thorough understanding of facial anatomy are critical for achieving optimal and safe outcomes.
Objective: To review and detail anatomically guided filler injection techniques for addressing hollowness in specific cheek regions, considering facial anatomy, ethnic variations, and patient-specific aesthetic goals.
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