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Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases.
Nat Genet
March 2025
Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Atrial fibrillation (AF) is the most common heart rhythm abnormality and is a leading cause of heart failure and stroke. This large-scale meta-analysis of genome-wide association studies increased the power to detect single-nucleotide variant associations and found more than 350 AF-associated genetic loci. We identified candidate genes related to muscle contractility, cardiac muscle development and cell-cell communication at 139 loci.
View Article and Find Full Text PDFBackground: Low dose corticosteroids (e.g., 6 mg dexamethasone) have been shown to reduce mortality for hypoxic COVID-19 patients.
View Article and Find Full Text PDFSearch for Magnetic Monopole Pair Production in Ultraperipheral Pb+Pb Collisions at sqrt[s_{NN}]=5.36 TeV with the ATLAS Detector at the LHC.
Phys Rev Lett
February 2025
CERN, Geneva, Switzerland.
This Letter presents a search for highly ionizing magnetic monopoles in 262 μb^{-1} of ultraperipheral Pb+Pb collision data at sqrt[s_{NN}]=5.36 TeV collected by the ATLAS detector at the LHC. A new methodology that exploits the properties of clusters of hits reconstructed in the innermost silicon detector layers is introduced to study highly ionizing particles in heavy-ion data.
View Article and Find Full Text PDFPlasma AR Alterations and Timing of Intensified Hormone Treatment for Prostate Cancer: the STAMPEDE Phase 3 Randomized Clinical Trial.
JAMA Oncol
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Department of Oncology, UCL Cancer Institute, University College London, London, United Kingdom.
The association between social vulnerability index and survival in older adults with gastrointestinal cancers - The CARE Registry.
J Geriatr Oncol
February 2025
Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL, USA; Division of Hematology & Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Introduction: Older adults represent a majority of gastrointestinal (GI) cancer cases. Social determinants of health, such as neighborhood-level social vulnerability index (SVI), are associated with frailty, a predictor of mortality. The association between social vulnerability and survival is understudied.
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