AI Article Synopsis
- The study simulates the dielectric behavior of interconnected cells, focusing on their actual shapes rather than simplified models.
- Using previous research, the team calculated the polarizability of non-spherical particles, which helped them compare the dielectric properties of cells connected by gap junctions with those of ellipsoidal particles.
- This research provides insights into how gap junction closure affects the dielectric behavior of ischemic tissues and offers an approximation of tissue properties when considering densely packed, oriented cells.
Article Abstract
The dielectric behaviour of interconnected cells is simulated by taking into account the 'real' shape. In previous work, we derived the polarizability of non-spherical, shelled, particles by solving the related integral equation using a spectral decomposition. The permittivity and impedance modulus spectra of gap junction connected cells are compared with those provided by a suspension of ellipsoids (prolate spheroids) having the same shape as the individual cells connected through gap junction, and the same volume fraction. This approach aims to provide a microscopic hint on the effect of the closing of gap junctions reported on the dielectric behaviour of ischaemic tissues, as well as to offer a rough approximation of a tissue by considering high concentrations of oriented gap junction connected cells.
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| http://dx.doi.org/10.1088/0031-9155/47/2/312 | DOI Listing |
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