During experimental hernioplasty with the application of the "Regeneration stimulator" in 38 dogs it was discovered that the rehabilitation period of the abdominal walls after the operation was considerably shorter. An experience with surgical treatment of 42 patients with postoperative ventral hernias is described. To remove the defect of the anterior abdominal wall by different intraoperative methods "the regeneration stimulator" was used in the zone of plasty. Recurrent hernias were noted in 1 of 42 patients. The method can be recommended for treatment of this category of patients.
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The analysis of enterosan influence on intestinal anastomosis healing in 90 rats was carried out. The medication is highly active as a regeneration stimulator. The use of enterosan decreases inflammation and activates regeneration in anastomosis area.
View Article and Find Full Text PDFNeurosci Behav Physiol
January 2005
Department of Histology, Cytology, and Embryology, Kazan' State Medical University.
Immunohistochemical studies were performed to address the expression of the high-molecular-weight component of the neurofilament triplet NF200 (a marker of neurons forming A fibers) and the binding of isolectin B4 (IB4) by neurons of the L4-5 spinal ganglia after ligation or section of the sciatic nerve in rats. A total of 15% of neurons in the ganglia of intact rats expressed NF200. By 90 days after nerve ligation, the proportion of NF200+ neurons decreased two-fold; administration to these rats of the nerve regeneration stimulator xymedone increased the number of NF200+ neurons by 50.
View Article and Find Full Text PDFMorfologiia
April 2004
Department of Histology, Cytology and Embryology, Kazan State Medical University.
An expression of high molecular component of neurofilament triplet NF200 (marker of neurons forming A-fibers) and binding of isolectin B4 (IB4) was examined immunohistochemically in LIV-LV dorsal root ganglia (DRG) neurons after ligation or transection of the sciatic nerve in rat. NF200 immunoreactivity was detected in 15% of all neurons in DRG of intact rats. Ligation of sciatic nerve caused a two-fold decrease in number of NF200-positive neurons by 90th day after nerve injury, however in animals treated with peripheral nerve regeneration stimulator xymedon the number of surviving NF200-positive neurons was increased by 50.
View Article and Find Full Text PDFBull Exp Biol Med
December 2002
Department of Histology, Cytology, and Embryology, Kazan State Medical University, Russia.
The survival of neurons is a key condition for complete posttraumatic regeneration of the peripheral nerve. In experiments on rats we studied survival capacity of different neuronal subpopulations in L(IV)-L(V) dorsal root ganglia after ligation or transection and suturing of the sciatic nerve. Experiments with nerve ligation showed that IB4+ neurons are more sensitive to the injury than NF200+ neurons.
View Article and Find Full Text PDFTreatment of extensive tissue defects should be complex, whose basis is an early free skin plastic repair with obligatory addition of agents that enhance the reparative capacities of tissues. For this, the authors propose a number of original appliances (forceps, variants of dermoperforators, bandage, etc.) and drugs, such as ximedon (tablets, 5-10% aqueous solution, lanolin-vaseline-based ointment, talc-based powder), whose clinical trials in 300 patients have shown their high therapeutical effect.
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