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Relationships and differentially expressed genes among pancreatic cancers examined by large-scale serial analysis of gene expression. | LitMetric

Relationships and differentially expressed genes among pancreatic cancers examined by large-scale serial analysis of gene expression.

Cancer Res

Department of Oncology, 451 Cancer Research Building, The Johns Hopkins Medical Institutions, 1650 Orleans Street, Baltimore, MD 21231, USA.

Published: February 2002

AI Article Synopsis

  • - Pancreatic adenocarcinoma is a highly lethal cancer, and its severity is partly due to late diagnosis and a lack of effective treatments, highlighting the need for in-depth studies of its biological mechanisms.
  • - Researchers analyzed gene expression profiles from pancreatic cancer cell lines, normal pancreatic tissue, and actual cancer tissues, using a method called serial analysis of gene expression, uncovering significant genetic insights.
  • - They discovered a pancreatic cancer cell line with a normal-like gene expression profile and identified several overexpressed genes, like S100A4 and mesothelin, that may serve as potential diagnostic markers and novel therapeutic targets.

Article Abstract

Pancreatic adenocarcinoma is among the most fatal of cancers, in part because of late diagnosis and a lack of effective therapies. Comprehensive studies are needed to better understand and address the cellular mechanisms and pathways of tumorigenesis. Serial analysis of gene expression was used to analyze gene expression profiles of pancreatic cancer cell lines, short-term cultures of normal pancreatic ductal epithelium, and primary pancreatic cancer tissue. A total of 294,920 tags representing 77,746 genes in 10 serial analysis of gene expression libraries were analyzed. A pancreatic cancer cell line (Hs766T) that exhibited a "normoid" profile of gene expression was identified. Several genes that may be involved in the fundamental nature of malignant changes in pancreatic ductal epithelium were suggested from those differentially and highly expressed in pancreatic cancer cells as compared with normal epithelium. Some overexpressed genes, such as S100A4, prostate stem cell antigen, carcinoembryonic antigen-related cell adhesion molecule 6, and mesothelin, suggest potential use as diagnostic markers. Others suggest potential novel therapeutic targets.

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