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WT1-mRNA dendritic cell vaccination of patients with glioblastoma multiforme, malignant pleural mesothelioma, metastatic breast cancer, and other solid tumors: type 1 T-lymphocyte responses are associated with clinical outcome.
J Hematol Oncol
January 2025
Center for Cell Therapy & Regenerative Medicine (CCRG), Antwerp University Hospital (UZA), Edegem, Belgium.
Cell therapies, including tumor antigen-loaded dendritic cells used as therapeutic cancer vaccines, offer treatment options for patients with malignancies. We evaluated the feasibility, safety, immunogenicity, and clinical activity of adjuvant vaccination with Wilms' tumor protein (WT1) mRNA-electroporated autologous dendritic cells (WT1-mRNA/DC) in a single-arm phase I/II clinical study of patients with advanced solid tumors receiving standard therapy. Disease status and immune reactivity were evaluated after 8 weeks and 6 months.
View Article and Find Full Text PDFComparative technoeconomic analysis of centralised and decentralised water source heat pump systems using CATHeaPS.
Heliyon
January 2025
James Watt School of Engineering, University of Glasgow, Glasgow, G12 8QQ, UK.
In the efforts to decarbonise the heat sector, heat pumps can offer a cost-effective transition away from fossil fuels. Water Source Heat Pumps (WSHP) can be utilised in cases where ambient water sources (river, ground water, abandoned mines water) are present. However, the economic benefits of different levels of heat pump centralisation as well as their comparative advantages over other decentralised options such as individual Air Source Heat Pumps (ASHP) or Gas Boilers (GB) remain uncertain and further investigations are necessary to fully assess their potential.
View Article and Find Full Text PDFIntegrating immunity, antioxidative status, and gene regulation against nickel and high-temperature stress in fish: selenium nanoparticles for mitigation.
Environ Sci Pollut Res Int
January 2025
ICAR-National Institute of Abiotic Stress Management, Baramati, Pune, 413 115, India.
Fish face health hazards due to high-temperature (T) stress and the toxicity associated with nickel (Ni), both of which can occur in aquatic ecosystems. The accumulation of nickel in fish may pose risks to human health when contaminated fish are consumed. Consequently, the goal of this study was to clarify how selenium nanoparticles (Se-NPs) help Pangasianodon hypophthalmus by reducing the effects of nickel and high-temperature stress.
View Article and Find Full Text PDFHealthcare resource utilization and costs of using Cariprazine as the first versus subsequent adjunctive therapy for major depressive disorder.
J Med Econ
January 2025
AbbVie, North Chicago, IL, USA.
Aim: Inadequate response to antidepressant therapy (ADT) is common in major depressive disorder (MDD); atypical antipsychotic (AA) adjunctive therapy may be effective for these patients. This study aimed to compare healthcare resource utilization (HRU) and costs between patients initiating the AA cariprazine as their first adjunctive therapy vs those initiating cariprazine subsequently.
Methods: The Merative MarketScan® Commercial Database (January 1, 2015, to June 30, 2021) was used to identify US adults with MDD and ≥1 pharmacy claim for cariprazine adjunctive to ADT in 2018 or after.
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