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Genotyping of SNPs in bread wheat at reduced cost from pooled experiments and imputation.
Theor Appl Genet
January 2024
Division of Scientific Computing, Department of Information Technology, Uppsala University, Lägerhyddsvägen 1, 75237, Uppsala, Sweden.
Pooling and imputation are computational methods that can be combined for achieving cost-effective and accurate high-density genotyping of both common and rare variants, as demonstrated in a MAGIC wheat population. The plant breeding industry has shown growing interest in using the genotype data of relevant markers for performing selection of new competitive varieties. The selection usually benefits from large amounts of marker data, and it is therefore crucial to dispose of data collection methods that are both cost-effective and reliable.
View Article and Find Full Text PDFIdentification of molecular mechanisms underlying the therapeutic effects of Celosia Cristata on immunoglobulin nephropathy.
Comput Biol Med
December 2022
College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, 712100, China. Electronic address:
Immunoglobulin A (IgA) nephropathy also known as Berger's disease, is a silent monster and perhaps the most prevalent glomerulonephritis that often accounts for end-stage kidney failure, thereby signifying a growing public health problem worldwide. The limited amount of available data and a broad spectrum of dysregulated physiological processes of IgAN make it a challenging task and a disproportionate economic load on the community health sector. Celosia cristata is an Amaranthaceous plant with attractive colorful inflorescences that are used in various regions of earth for the treatment of numerous ailments.
View Article and Find Full Text PDFInhibition of cancer cell-derived exosomal microRNA-183 suppresses cell growth and metastasis in prostate cancer by upregulating TPM1.
Cancer Cell Int
March 2021
Department of Pathology and Pathophysiology, College of Basic Medical Science, Guizhou Medical University, Guiyang, 550004, People's Republic of China.
Background: Emerging evidence continues to highlight the significant role of microRNAs (miRNAs) in the regulation of cancer growth and metastasis. Herein, the current study aimed to elucidate the role of exosomal miR-183 in prostate cancer development.
Methods: Initially, public microarray-based gene expression profiling of prostate cancer was employed to identify differentially expressed miRNAs.
A novel synthetic-genetic-array-based yeast one-hybrid system for high discovery rate and short processing time.
Genome Res
August 2019
State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin 150040, China.
Eukaryotic gene expression is often tightly regulated by interactions between transcription factors (TFs) and their DNA targets. Yeast one-hybrid (Y1H) is one of the most extensively used methods to discover these interactions. We developed a high-throughput meiosis-directed yeast one-hybrid system using the Magic Markers of the synthetic genetic array analysis.
View Article and Find Full Text PDFIntegrative Metabolomic and Transcriptomic Analysis for the Study of Bladder Cancer.
Cancers (Basel)
May 2019
Unidad Mixta de Investigación en Nanomedicina y Sensores, Universitat Politècnica de València-Instituto de Investigación Sanitaria La Fe, 46026 Valencia, Spain.
Metabolism reprogramming is considered a hallmark of cancer. The study of bladder cancer (BC) metabolism could be the key to developing new strategies for diagnosis and therapy. This work aimed to identify tissue and urinary metabolic signatures as biomarkers of BC and get further insight into BC tumor biology through the study of gene-metabolite networks and the integration of metabolomics and transcriptomics data.
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