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Facet engineering of CuO for efficient electrochemical glucose sensing.
Anal Chim Acta
January 2025
Hubei Provincial Key Laboratory of Green Materials for Light Industry, School of Materials and Chemical Engineering, Hubei University of Technology, Wuhan, 430068, PR China. Electronic address:
Background: Accurate monitoring glucose level is significant for human health management, especially in the prevention, diagnosis, and management of diabetes. Electrochemical quantification of glucose is a convenient and rapid detection method, and the crucial aspect in achieving great sensing performance lies in the selection and design of the electrode material. Among them, CuO, with highly catalysis ability, is commonly used as electrocatalyst in non-enzymatic glucose sensing.
View Article and Find Full Text PDFThe arcana of zinc.
J Nutr
January 2025
Department of Nutritional Sciences, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King's College London, London. Electronic address:
This perspective discusses that the essential micronutrient zinc has functions in over 3000 human proteins (the zinc proteome), and the implications of three aspects to ascertain an adequate zinc status for human health. First, the advent of highly sensitive fluorescent (bio)chemicals revealed cellular pools of zinc ions involved in signalling and secretion from cells for paracrine, autocrine, and possibly endocrine functions. Zinc signalling adds a yet unaccounted number of targeted proteins to the already impressive number of zinc proteins.
View Article and Find Full Text PDFBackground: Alzheimer's disease (AD) is a highly complex neurological disorder, with Late-Onset AD (LOAD) being its most common form. INPP5D has been identified as a risk gene for AD and is involved in the TREM2 signaling pathway, which is crucial for microglial activity. INPP5D encodes SHIP1, a protein phosphatase that disrupts TREM2 signaling by converting PIP3 into PIP2, thereby inhibiting the PI3K-mediated activation of Akt-dependent signaling, which is essential for the clearance of amyloid oligomers, fibrils, and plaques.
View Article and Find Full Text PDFTwenty-four weeks of combined training in different environments, aquatic and land, in the type 2 diabetes management (Aquatic and Land Exercise for Diabetes -ALED): protocol of a randomized clinical trial.
Trials
January 2025
Department of Physical Education, Sports Center, Federal University of Santa Catarina, University Campus Trindade, Florianópolis, Santa Catarina, 88040-900, Brazil.
Background: Physical exercise is crucial in type 2 diabetes management (T2D), and training in the aquatic environment seems to be a promising alternative due to its physical properties and metabolic, functional, cardiovascular, and neuromuscular benefits. Research on combined training in aquatic and dry-land training environments is scarce, especially in long-term interventions. Thus, this study aims to investigate the effects of combined training in both environments on health outcomes related to the management of T2D patients.
View Article and Find Full Text PDFThe 18th International Zebrafish Conference (IZFC2024) took place from August 17 to 21, 2024, at Miyako Messe in Kyoto, Japan. This conference attracted 641 researchers from around the world along with 83 virtual participants, making it the largest gathering since the COVID-19 pandemic. The event featured two keynote lectures, three award lectures, 36 plenary talks, 90 oral presentations, and 374 poster presentations.
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