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Antioxidative and Anti-Atopic Dermatitis Effects of Peptides Derived from Hydrolyzed Tail By-Products.

Mar Drugs

October 2024

Department of Medical Laboratory Science, College of Health Science, Dankook University, Cheonan-si 31116, Chungcheongnam-do, Republic of Korea.

Atopic dermatitis (AD) is a chronic inflammatory skin disorder associated with significant morbidity, including pruritus, recurrent skin lesions, and immune dysregulation. This study aimed to investigate the antioxidative and anti-AD effects of peptides derived from hydrolyzed (Korea rockfish) tail by-products. Hydrolysates were prepared using various enzymes, including Alcalase, Flavourzyme, Neutrase, and Protamex.

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[Effects of ferulic acid on allergic reaction].

Zhongguo Yao Li Xue Bao

September 1991

Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing.

Ferulic acid (FA) 70, 140 mg.kg-1 ip clearly inhibited homologous passive cutaneous anaphylaxis (PCA) and degranulation of mast cells of calvarial periosteum, active and passive Arthus reactions in rats. Reversed cutaneous anaphylaxis in rats and Forssman cutaneous vasculitis in guinea pigs were suppressed by FA 140 mg.

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We examined natural killer (NK) cell activity and delayed-type hypersensitivity reaction to 2,4-dinitrochlorbenzene (DNCB) in the spectrum of chronic, intractable pulmonary tuberculosis. A high reactive group as defined by high NK cell activity and positive reaction to DNCB were characterised by stable clinical courses assessed by radiographical and clinical changes. A low reactive group defined by non-augmented NK cell activity and negative reaction to DNCB were characterised by progressive clinical courses.

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126 chemical compounds were tested in the Ames assay with bacterial Salmonella typhimurium of 8 various strains (mainly TA 98 & TA100). For metabolic activation liver S9 from arochlortreated rats was used. In the first group of substances tested (51 compounds with confirmed carcinogenicity for animals) 45 agents possessed mutagenicity and 6 gave false-negative response (1.

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One-hundred and six chemical compounds were tested in Ames test with bacteria Salmonella typhimurium. Eight different strains (mainly, TA98 and TA100) were used. Liver S9 from Aroclor-treated rats was employed for metabolic activation.

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