AI Article Synopsis
- Peptide YY (PYY) is a hormone produced in the distal gut that is linked to the growth of intestinal epithelial cells.
- Research shows that gut cells have receptors for PYY, which stimulates their proliferation both in living organisms and in lab settings.
- Besides its normal role in maintaining gut health, the hormonal effects of PYY might also play a part in unhealthy excessive growth in intestinal tissues.
Article Abstract
Peptide YY is an abundant distal gut hormone that may play a significant role in intestinal epithelial proliferation. Gut epithelial cells express specific receptors for PYY, PYY induces proliferation in intestinal cells in vivo and in vitro, and the Y1 receptor subtype couples to mitogenic signaling pathways. In addition to proposed physiologic effects on gut mucosal maintenance, PYY proliferative effects may be hypothesized to contribute to pathophysiologic consequences of stimulated growth.
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| http://dx.doi.org/10.1016/s0196-9781(01)00615-5 | DOI Listing |
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