In 1853, the British physiologist Thomas Henry Huxley roundly criticized German cell theory. Historians have had difficulty explaining how such a 'progressive' biologist could have rejected cellular autonomy and the central role of the nucleus in cell life. The key to Huxley's thinking is provided by understanding his 'epigenetic' philosophy of biology.
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Enhancer cooperativity can compensate for loss of activity over large genomic distances.
Mol Cell
January 2025
Max Perutz Laboratories, Vienna BioCenter Campus (VBC), Dr.-Bohr-Gasse 9, 1030 Vienna, Austria; University of Vienna, Center for Molecular Biology, Department of Microbiology, Immunobiology, and Genetics, Dr.-Bohr-Gasse 9, 1030 Vienna, Austria. Electronic address:
Enhancers are short DNA sequences that activate their target promoter from a distance; however, increasing the genomic distance between the enhancer and the promoter decreases expression levels. Many genes are controlled by combinations of multiple enhancers, yet the interaction and cooperation of individual enhancer elements are not well understood. Here, we developed a synthetic platform in mouse embryonic stem cells that allows building complex regulatory landscapes from the bottom up.
View Article and Find Full Text PDFUsing high-frequency oscillations from brief intraoperative neural recordings to predict the seizure onset zone.
Commun Med (Lond)
November 2024
Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, 55905, USA.
Background: While high-frequency oscillations (HFOs) and their stereotyped clusters (sHFOs) have emerged as potential neuro-biomarkers for the rapid localization of the seizure onset zone (SOZ) in epilepsy, their clinical application is hindered by the challenge of automated elimination of pseudo-HFOs originating from artifacts in heavily corrupted intraoperative neural recordings. This limitation has led to a reliance on semi-automated detectors, coupled with manual visual artifact rejection, impeding the translation of findings into clinical practice.
Methods: In response, we have developed a computational framework that integrates sparse signal processing and ensemble learning to automatically detect genuine HFOs of intracranial EEG data.
(E, E)-farnesol and myristic acid-loaded lipid nanoparticles overcome colistin resistance in Acinetobacter baumannii.
Int J Pharm
December 2024
Université de Poitiers, PHAR2, INSERM U1070, Poitiers, France. Electronic address:
The rise of colistin-resistant Acinetobacter baumannii has severely limited treatment options for infections caused by this pathogen. While terpene alcohols and fatty acids have shown potential to enhance colistin's efficacy, but their high lipophilicity limits their clinical application. To address this, we developed water-dispersible lipid nanoparticles (LNPs) in two sizes (40 nm and 130 nm), loaded with these compounds to act as colistin adjuvants.
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- Tuberculosis (TB) affects people differently, and regular lab mice don't show this variety in their responses to the disease.
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Assessing expert reliability in determining intracranial EEG channel quality and introducing the automated bad channel detection algorithm.
J Neural Eng
July 2024
Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, United States of America.
To evaluate the inter- and intra-rater reliability for the identification of bad channels among neurologists, EEG Technologists, and naïve research personnel, and to compare their performance with the automated bad channel detection (ABCD) algorithm for detecting bad channels.Six Neurologists, ten EEG Technologists, and six naïve research personnel (22 raters in total) were asked to rate 1440 real intracranial EEG channels as good or bad. Intra- and interrater kappa statistics were calculated for each group.
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