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Youth living with HIV (YLWH) have high rates of virologic failure due to medication non-adherence. is a novel, gamified mobile health (mHealth) application designed with user-centered principles to improve medication adherence by integrating medication reminders with social and financial incentives, virtual peer social support and early clinic outreach for non-adherent YLWH in Nigeria. Focus Group Discussions (FGDs) were conducted to identify reactions to key prototype features (user interface, medication reminders, incentives, and peer support), facilitators and barriers to app use, and how well the app would meet adherence needs.
View Article and Find Full Text PDFDesigning of an mRNA vaccine against high-risk human papillomavirus targeting the E6 and E7 oncoproteins exploiting immunoinformatics and dynamic simulation.
PLoS One
January 2025
Microbiology, Cancer and Bioinformatics Research Group, Noakhali Science and Technology University, Noakhali, Bangladesh.
Human papillomavirus 16 and human papillomavirus 18 have been associated with different life-threatening cancers, including cervical, lung, penal, vulval, vaginal, anal, and oropharyngeal cancers, while cervical cancer is the most prominent one. Several research studies have suggested that the oncoproteins E6 and E7 are the leading cause of cancers associated with the human papillomavirus infection. Therefore, we developed two mRNA vaccines (V1 and V2) targeting these oncoproteins.
View Article and Find Full Text PDFIndividual and community-level determinants of knowledge of obstetric danger signs among women in Southern Ethiopia: A multi-level mixed effect negative binomial analysis.
PLoS One
January 2025
School of Public Health, College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia.
Introduction: One of the key strategies to achieve the sustainable development goal by reducing maternal deaths below 70 per 100,000 is improving knowledge of obstetric danger signs (ODS). However, mothers' knowledge of ODS is low in general and very low in rural settings, regardless of local and national efforts in Ethiopia. Further, there is significant variation of ODS knowledge among women from region to region and urban/rural settings.
View Article and Find Full Text PDFDroplet-Scale Conversion of Aluminum into Transparent Aluminum Oxide by Low-Voltage Anodization in an Electrowetting System.
Langmuir
January 2025
Information Device Science Laboratory, Division of Materials Science, Nara Institute of Science and Technology, Ikoma City, Nara 630-0192, Japan.
A localized conversion of aluminum into transparent aluminum oxide by droplet-scale anodization is demonstrated in this work. The anodized region can be contained and controlled on the basis of the electrowetting response of the droplet. A highly uniform and transparent anodized spot was achieved using an anodization voltage of 2 V for 10 min.
View Article and Find Full Text PDFPhotocatalytic Semiconductor-Metal Hybrid Nanoparticles: Single-Atom Catalyst Regime Surpasses Metal Tips.
ACS Nano
January 2025
Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel.
Semiconductor-metal hybrid nanoparticles (HNPs) are promising materials for photocatalytic applications, such as water splitting for green hydrogen generation. While most studies have focused on Cd containing HNPs, the realization of actual applications will require environmentally compatible systems. Using heavy-metal free ZnSe-Au HNPs as a model, we investigate the dependence of their functionality and efficiency on the cocatalyst metal domain characteristics ranging from the single-atom catalyst (SAC) regime to metal-tipped systems.
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