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Discovery of a MET-driven monogenic cause of steatotic liver disease.
Hepatology
January 2025
Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.
Background Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) affects about a third of adults worldwide and is projected soon to be the leading cause of cirrhosis. It occurs when fat accumulates in hepatocytes and can progress to metabolic dysfunction-associated steatohepatitis (MASH), liver cirrhosis, and hepatocellular carcinoma. MASLD pathogenesis is believed to involve a combination of genetic and environmental risk factors.
View Article and Find Full Text PDFImproved Risk Adjustment for Comorbid Diagnoses in Administrative Claims Analyses of Orthopaedic Surgery.
J Bone Joint Surg Am
January 2025
Department of Orthopaedic Surgery, Stanford University, Redwood City, California.
Background: The accurate inclusion of patient comorbidities ensures appropriate risk adjustment in clinical or health services research and payment models. Orthopaedic studies often use only the comorbidities included at the index inpatient admission when quantifying patient risk. The goal of this study was to assess improvements in capture rates and in model fit and discriminatory power when using additional data and best practices for comorbidity capture.
View Article and Find Full Text PDFMotorcycle and Equestrian Trauma: An ACS TQIP Comparative Study.
J Trauma Nurs
January 2025
Department of Surgery, Morristown Medical Center, Morristown, New Jersey.
Background: Motorcycle and equestrian accidents can share similar trauma mechanisms and can result in serious injuries.
Objective: This study aims to analyze variations in injuries and safety standards through types, severity, and outcomes of traumatic injuries in both motorcycle and equestrian riders.
Methods: Using the 2020 ACS TQIP database, we split patients into two groups based on their primary injury.
Assessing the role of Alnus nepalensis D. Don in stabilizing landslide and its potential distribution: a case study from Uttarakhand, Western Himalaya.
Integr Environ Assess Manag
January 2025
Department of Environmental Science, GITAM Deemed to be University, Visakhapatnam, India.
The rising frequency and severity of landslides in the vulnerable Himalayan region of India threaten human settlements and critical infrastructure. This growing issue demands urgent action and innovative strategies to mitigate risks and bolster the resilience of affected communities and infrastructure in this fragile area. The research explores the use of Alnus nepalensis for slope stabilization, illustrated by a case study near Ukhimath, Uttarakhand, India, and elucidates the potential ecological niche of Alnus in the temperate region of Uttarakhand using well-dispersed species occurrence records along with environment.
View Article and Find Full Text PDFDevelopment and implementation of an electronic health record system for use in humanitarian emergencies, disaster response, and conflict zones.
PLOS Glob Public Health
January 2025
Center for Global Health, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Humanitarian medical response to natural and human-made disasters can be complicated by high clinician, staff, and patient turnover. While electronic medical records are being scaled up globally, their use remains limited in humanitarian response settings. The Fast Electronic Medical Record (fEMR) system is an open-source electronic health record system specifically designed for use in resource-limited settings and humanitarian crises.
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