AI Article Synopsis
- - The North spiroketal structure of ritterazine M has been updated from an incorrect version (1a) to the correct one (1b) based on spectral comparisons.
- - This correction was validated by comparing it to five synthetic spiroketal-alcohol models that were created for analysis.
- - The synthesis of these models involved a series of chemical reactions, including reductive cleavage, asymmetric dihydroxylation, and oxidative spirocyclization techniques.
Article Abstract
The structure of the North spiroketal moiety of ritterazine M has been corrected from 1a to 1b. This was accomplished by comparison of published spectra of the natural product with five synthetic spiroketal-alcohols. Synthesis of these models was efficiently accomplished by reductive cleavage of the spiroketal and Sharpless asymmetric dihydroxylation of an isopentyl, methyl 1,1-disubstituted olefin, followed by Suarez iodine[III] oxidative spirocyclization of monoprotected 1 degree,3 degree 1,2 diols.
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| http://dx.doi.org/10.1021/ol0165894 | DOI Listing |
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