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| http://dx.doi.org/10.3748/wjg.v6.i3.430 | DOI Listing |
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Simultaneous Down-Regulation of Intracellular MicroRNA-21 and hTERT mRNA Using AS1411-Functionallized Gold Nanoprobes to Achieve Targeted Anti-Tumor Therapy.
Nanomaterials (Basel)
December 2024
School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, China.
Telomerase presents over-expression in most cancer cells and has been used as a near-universal marker of cancer. Studies have revealed that inhibiting telomerase activity by utilizing oligonucleotides to down-regulate the expression of intracellular human telomerase reverse-transcriptase (hTERT) mRNA is an effective method of achieving anti-tumor therapy. Considering that oncogenic microRNA-21 has been proven to indirectly up-regulate hTERT expression and drive cancer metastasis and aggression through increased telomerase activity, here, we constructed an AS1411-functionallized oligonucleotide-conjugated gold nanoprobe (Au nanoprobe) to simultaneously down-regulate intracellular microRNA-21 and hTERT mRNA by using anti-sense oligonucleotide technology to explore their targeted anti-tumor therapy effect.
View Article and Find Full Text PDFBeginning at the ends: telomere and telomere-based cancer therapeutics.
Mol Genet Genomics
December 2024
Department of Medical Genetics, School of Medicine, Iranshahr University of Medical Sciences, Iranshahr, Iran.
Telomeres, which are situated at the terminal ends of chromosomes, undergo a reduction in length with each cellular division, ultimately reaching a critical threshold that triggers cellular senescence. Cancer cells circumvent this senescence by utilizing telomere maintenance mechanisms (TMMs) that grant them a form of immortality. These mechanisms can be categorized into two primary processes: the reactivation of telomerase reverse transcriptase and the alternative lengthening of telomeres (ALT) pathway, which is dependent on homologous recombination (HR).
View Article and Find Full Text PDFAssociation between human telomerase reverse transcriptase (hTERT) MNS16A polymorphism and risk of breast cancer.
Mol Biol Rep
October 2024
Department of Biology, School of Science, Shiraz University, Shiraz, 71467-13565, Iran.
Article Synopsis
- - The study investigates the role of the MNS16A genetic polymorphism in the hTERT gene and its possible link to breast cancer risk, given that telomerase activity is usually low in normal tissues but increased in tumors.
- - Researchers analyzed 711 samples, including 362 breast cancer patients and 349 healthy individuals, using DNA genotyping to assess the presence of short and long alleles related to the MNS16A polymorphism.
- - Results showed no significant association between the MNS16A polymorphism and breast cancer risk across various genetic models, indicating the need for further research with larger populations to explore this relationship.
TERRA transcripts localize at long telomeres to regulate telomerase access to chromosome ends.
Sci Adv
June 2024
Laboratory of Cell Biology and Molecular Genetics, Department CIBIO, University of Trento, via Sommarive 9, 38123 Trento, Italy.
The function of TERRA in the regulation of telomerase in human cells is still debated. While TERRA interacts with telomerase, how it regulates telomerase function remains unknown. Here, we show that TERRA colocalizes with the telomerase RNA subunit hTR in the nucleoplasm and at telomeres during different phases of the cell cycle.
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