AI Article Synopsis
- * Researchers used a method called immunohistochemistry to observe specific integrins (alpha(1), alpha(2), alpha(3), and alpha(5)) and epidermal keratin in liver tissues under different conditions, from normal to cancerous.
- * Results showed that while integrin expression decreases in cancerous tissues, integrins alpha(1) and alpha(5) are more prevalent in metastatic (spread) tumors, suggesting these integrins might be significant for liver cancer
Article Abstract
AIM:To investigate the expression of integrins in rats liver during 3'-Me -DAB induced hepatocarcinogenesis and to find out the relationship between integrins and liver cancer metastasis.METHODS:The expressions of integrins alpha(1), alpha(2), alpha(3) and alpha(5) and epidermal keratin (EK) were observed by immunohisto chemical PAP method.RESULTS:In the normal liver tissues, hepatocytes express integrins alpha(1) and alpha(5) and in the bile duct epithlium, EK. In liver cirrhosis, hepatocytes highly express integrins alpha(1), alpha(2), alpha(3) and alpha5and in hyperplastic bile duct epithelium, integrins alpha(1), alpha(5) and EK. Expression of integrins alpha(1), alpha(2), alpha(3) and alpha(5) were obviously decreased in the preneoplastic nodules and primary carcinoma but expressions of integrins alpha(1) and alpha(5) in metastasis in the lung and diaphragma were higher than those in primary carcinoma.CONCLUSION:Integrins alpha(1) and alpha(5) may play a major role in chemically induced hepatocarcinogenesis and metastasis in rats.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723491 | PMC |
| http://dx.doi.org/10.3748/wjg.v6.i2.231 | DOI Listing |
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