AI Article Synopsis
- The study aimed to investigate how halothane causes liver toxicity by examining its effects on mitochondrial membrane components.
- Researchers used high performance liquid chromatography (HPLC) to analyze the impact of halothane and sevoflurane on rat liver phospholipids.
- Findings revealed that low concentrations of halothane led to degradation of key mitochondrial phospholipids and an increase in lysophosphatidylcholine, suggesting that changes in liver mitochondrial phospholipids contribute to halothane's hepatotoxic effects.
Article Abstract
AIM:To study the pathogenesis of hepatotoxicity of halothane.METHODS:The effect of different concentration of halothane and sevoflurane on mitochondrial membrane phospholipids composition of rat liver were analyzed using high performance liquid chromatography (HPLC) technology.RESULTS:Halothane at low concentration could degrade mitochondrial membrane major phospholipids and increase lysophosph-atidylcholine.CONCLUSION:The pathogenesis of halothane hepatotoxicity was the phospholipids variation on liver mitochondria.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688493 | PMC |
| http://dx.doi.org/10.3748/wjg.v5.i1.28 | DOI Listing |
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