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Is It All in Your Head? Placebo Effects in Concussion Prevention.
Sports Med
January 2025
School of Health Sciences, Swinburne University of Technology, Melbourne, VIC, Australia.
Sports-related concussions (SRCs) are a major health issue in athletes of varying ages, ability levels, and sports. Concerns over the short- and long-term consequences of SRCs have incentivized a wealth of products and policies aimed at reducing SRC risk. Research suggesting the effectiveness of such interventions at reducing SRCs has facilitated their adoption by sports organizations and, in some cases, product commercialization.
View Article and Find Full Text PDFEffect of Preoperative Carbohydrate Loading on Postoperative Recovery of Individuals Who Have Type 2 Diabetes After Total Knee Arthroplasty: A Randomized Controlled Trial.
J Arthroplasty
September 2024
Department of Orthopaedic Surgery, West China Hospital of Sichuan University, Chengdu, China.
Background: Many individuals undergoing surgery involving general anesthesia are asked to fast for a prolonged period to ensure perioperative safety, yet this can initiate stress reactions and insulin resistance, harming postoperative recovery. Such fasting may be particularly problematic for those who have type 2 diabetes. Here, we assessed how giving such individuals' oral carbohydrates before total knee arthroplasty can affect outcomes.
View Article and Find Full Text PDFRandomized placebo controlled trial of phytoterpenes in DMSO for the treatment of plantar fasciitis.
Sci Rep
July 2024
Institute for Biomedical Sciences, 967 East Parkcenter Blvd, Ste 205, Boise, ID, 83706, USA.
Plantar fasciitis is the most common cause of heel pain in adults with an overall prevalence of 0.85% in the adult population of the US, affecting over 2 million adults annually. Most current treatment modalities are not supported by sufficient evidence to recommend one particular strategy over another.
View Article and Find Full Text PDFOnce-weekly semaglutide in people with HIV-associated lipohypertrophy: a randomised, double-blind, placebo-controlled phase 2b single-centre clinical trial.
Lancet Diabetes Endocrinol
August 2024
Department of Medicine, Division of Infectious Diseases, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Article Synopsis
- HIV-associated lipohypertrophy is a condition marked by excess abdominal fat in people living with HIV, leading to increased health risks, and current treatment options are insufficient.
- A clinical trial tested the effectiveness of semaglutide, a GLP-1 receptor agonist, in reducing this abnormal fat accumulation among HIV patients without diabetes.
- Results showed significant decreases in abdominal visceral fat and total body fat after 32 weeks of treatment with semaglutide compared to placebo, indicating its potential as an effective intervention for lipohypertrophy in this population.
Effect of N-acetylcysteine on neural alcohol cue reactivity and craving in adolescents who drink heavily: A preliminary randomized clinical trial.
Alcohol Clin Exp Res (Hoboken)
September 2024
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
Background: Alcohol craving is related to problematic alcohol use; therefore, pharmacotherapies that modulate alcohol craving are of interest. N-acetylcysteine, an over-the-counter antioxidant, is a candidate pharmacotherapy for adolescent alcohol use with the potential to impact craving. Cue-reactivity paradigms using functional magnetic resonance imaging (fMRI) can identify neural regions implicated in craving and serve as a screening tool for novel pharmacotherapy options.
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