Objectives: Dichlorodiphenyl dichloroethene (DDE) and polychlorinated biphenyls (PCB), toxic contaminants known to be persistent in the environment, may affect growth. We investigated whether growth from birth to 10 years of age is associated with blood concentrations of DDE and PCB taken at 8 years of age.
Study Design: We ambispectively followed up a cohort of 343 German children. DDE and PCB blood concentrations were determined in 1995. Height measurements were conducted prospectively between 1994 and 1997 and obtained retrospectively from each Child's Health Card. Linear regression models for repeated measurements, controlling for confounding factors, were applied.
Results: Growth was significantly reduced by an average of 1.8 cm (P <.0275) for girls in the highest DDE concentration quartile (>.44 microg/L in whole blood) compared with girls in the lowest quartile (0.08-0.2 microg/L). There was no observed growth effect of DDE in boys. PCB blood concentrations were not related to growth reduction in either girls or boys.
Conclusions: Background level concentrations to DDE, but not PCB, during childhood are associated with a small reduction in growth for girls evident through the age of 8 years. The observed differences narrow at the year 9 examination and disappear at the year 10 examination. No effects on boys' heights were observed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1067/mpd.2002.120764 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Unveiling the toxicity of micro-nanoplastics: A systematic exploration of understanding environmental and health implications.
Toxicol Rep
June 2025
Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur 56000, Malaysia.
The surge in plastic production has spurred a global crisis as plastic pollution intensifies, with microplastics and nanoplastics emerging as notable environmental threats. Due to their miniature size, these particles are ubiquitous across ecosystems and pose severe hazards as they are ingested and bioaccumulate within organisms. Although global plastic production has reached an alarming 400.
View Article and Find Full Text PDFHDL-associated vitamin D binding protein levels are inversely associated with necrotic plaque burden in psoriasis.
Atheroscler Plus
March 2025
Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Background And Aims: Vitamin D binding protein (DBP) serves a dual function as a vitamin D carrier and actin scavenger. Free DBP is present in high concentrations in serum, while a smaller pool is bound to lipoproteins like HDL and VLDL. The role of DBP's interaction with lipoproteins remains unclear.
View Article and Find Full Text PDFChanges in hematological and hematochemical parameters in lactating dairy sheep according to different pasture management and heat stress risk: A longitudinal study.
Vet Anim Sci
March 2025
Department of Agriculture, Food and Environment, University of Pisa, 56124 Pisa, Italy.
Sheep in Italy are exposed to heat stress (HS) for several months, increasing the risk of HS-related problems such as the decrease in growth, reproductive performance, milk quantity and quality and natural immunity. This study aimed to assess changes in hematological and biochemical parameters in dairy sheep from three different farms with varying pasture management: A (no water or shade), B (water but no shade), and C (both water and shade). From March to June, when HS risk is high, monthly blood samples (T1-T4) were collected from 20 sheep per farm (total n = 60).
View Article and Find Full Text PDFTherapeutic doses of efzofitimod demonstrate efficacy in pulmonary sarcoidosis.
ERJ Open Res
January 2025
Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Background: In a phase 1b/2a clinical trial of efzofitimod in patients with corticosteroid-requiring pulmonary sarcoidosis, treatment resulted in dose-dependent improvement in key end-points. We undertook a analysis pooling dose arms that achieved therapeutic concentrations of efzofitimod (Therapeutic group) those that did not (Subtherapeutic group).
Methods: Peripheral blood mononuclear cells incubated with tuberculin-coated beads were exposed to varying concentrations of efzofitimod in an assay to determine concentrations that inhibited granuloma formation.
Prognostic model for esophagogastric variceal rebleeding after endoscopic treatment in liver cirrhosis: A Chinese multicenter study.
World J Gastroenterol
January 2025
Cell Biology Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Background: Rebleeding after recovery from esophagogastric variceal bleeding (EGVB) is a severe complication that is associated with high rates of both incidence and mortality. Despite its clinical importance, recognized prognostic models that can effectively predict esophagogastric variceal rebleeding in patients with liver cirrhosis are lacking.
Aim: To construct and externally validate a reliable prognostic model for predicting the occurrence of esophagogastric variceal rebleeding.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!