AI Article Synopsis
- - McCune-Albright syndrome (MAS) is a rare condition marked by abnormal bone growth, skin spots, and hormone imbalances, primarily affecting children.
- - A case study of a 2.5-year-old child revealed MAS with an unusual early onset, presenting mostly with frequent fractures and a diagnosis of hyperthyroidism, despite lacking typical symptoms.
- - Currently, there is no established treatment for managing bone and thyroid issues in children with MAS who are under 6 years old, and it's uncertain how thyroid problems relate to the severity of bone conditions.
Article Abstract
McCune-Albright syndrome (MAS) is a sporadic disease characterized by fibrous bone dysplasia, café-au-lait spots and hyperfunctional endocrinopathies. We report a 2.5-year-old child with MAS with an early and nonclassic onset. He was admitted to our attention for frequent fractures without clinical signs of endocrinopathies, found to have asymptomatic, nonautoimmune hyperthyroidism. The diagnosis of MAS was based on RX and MR imaging associated with hyperthyroidism. It is not clear if there was a correlation between the severity of bone disease and the presence of thyroid disorder. At the moment no standard treatment exists for bone fibrous dysplasia and hyperthyroidism in children before the age of 6 years.
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| http://dx.doi.org/10.1159/000048091 | DOI Listing |
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