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Generation of a small library of cyclodepsipeptide PF1022A analogues using a cyclization-cleavage method with oxime resin. | LitMetric
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Generation of a small library of cyclodepsipeptide PF1022A analogues using a cyclization-cleavage method with oxime resin.

Byung H Lee Fred E Dutton David P Thompson Eileen M Thomas

Bioorg Med Chem Lett

Discovery Research, Pharmacia Animal Health, Kalamazoo, MI 49001, USA.

Published: February 2002

N-Methyloctadepsipeptides attached to an oxime resin were cyclized by heating them in refluxing ethyl acetate for 2 days to give cyclodepsipeptide PF1022A analogues. By using this method, we generated a small library of PF 1022A analogues (2), several of which possessed anthelmintic activity, based on an in vitro assay.

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http://dx.doi.org/10.1016/s0960-894x(01)00748-xDOI Listing

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