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Extracranial and nonvaginal extragonadal malignant germ cell tumors: 12 cases at a Chinese institution over the last 38 years.
Arch Gynecol Obstet
January 2025
Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetric & Gynecologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Purpose: To provide a comprehensive understanding and propose a strategy for the management of extragonadal malignant germ cell tumors (EMGCTs) arising from extracranial and nonvaginal sites.
Methods: We retrospectively reviewed the cases of 12 patients with EMGCTs arising from extracranial and nonvaginal sites treated in our center over the past 38 years. Data on clinicopathological characteristics, treatment modalities, and follow-up information were analyzed.
Successful Treatment Outcome of a Pediatric Malignant Germ Cell Tumor With an Extensive Cavo-atrial Tumor Thrombus Presenting as an Oncological Emergency.
J Pediatr Hematol Oncol
January 2025
Department of Pediatric Oncology, Regional Cancer Centre.
Background: Pediatric germ cell tumor (GCT) with extensive cavo-atrial tumor thrombus presenting as an oncologic emergency is extremely rare.
Observation: A 13-month-old female child with sacrococcygeal GCT having inferior vena cava (IVC) and right atrial thrombus presenting with anasarca and respiratory distress is reported. Because of worsening symptoms post initiation of chemotherapy, tumor thrombus debulking from the right atrium and distal end of IVC was performed on day 9 on an emergency basis.
Early Outcomes of the Surgical Treatment of Sacrococcygeal Tumors in a Tertiary Level Government Hospital.
Acta Med Philipp
October 2024
Division of Pediatric Surgery, Department of Surgery, Philippine General Hospital, University of the Philippines Manila.
Article Synopsis
- Sacrococcygeal teratomas (SCT) are the most frequent tumors found outside the gonads in young children, but there's limited data on their clinical features and outcomes in the Philippines, as the existing studies have mostly come from other countries.* -
- This study was retrospective and collected data over four years from medical records, focusing on demographics, delivery methods, clinical presentations, tumor classifications, and surgical outcomes, including mortality, morbidity, and recurrence rates.* -
- Out of 29 patients analyzed, most were female, and many presented with a sacral or gluteal mass, but only a small percentage received an accurate prenatal ultrasound diagnosis; imaging methods were used to further evaluate the tumors, with
Yolk-sac carcinoma mimicking sacrococcygeal teratoma in an infant.
Radiol Case Rep
January 2025
Department of General surgery, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.
Article Synopsis
- Extragonadal germ cell tumors (GCTs) are rare, making up only 1% to 5% of all GCTs, and include malignant sacrococcygeal yolk sac tumors (SCYSTs) mainly found in children and young adults.
- An 8-month-old girl presented with abdominal distension and urinary difficulties, leading to the discovery of a pelvic mass that required surgical removal, which was diagnosed as a malignant yolk sac tumor.
- Despite surgery and chemotherapy, the tumor returned, indicating the complexity of managing SCYSTs and the necessity for a team of specialists and updated treatment guidelines.
Sacrococcygeal teratoma (SCT), a rare germ cell malignancy in newborns, necessitates prompt surgical intervention for complete resection. Long-term follow-up is crucial for monitoring recurrence and managing potential complications, regardless of histopathological findings, ensuring optimal outcomes and early intervention if needed.
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