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An aptamer-guided fluorescence polarisation platform for extracellular vesicle liquid biopsy.
J Extracell Vesicles
September 2024
State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai, China.
The translation of discoveries on extracellular vesicle (EV) based cancer biomarkers to personalised precision oncology requires the development of robust, sensitive and specific assays that are amenable to adoption in the clinical laboratory. Whilst a variety of elegant approaches for EV liquid biopsy have been developed, most of them remain as research prototypes due to the requirement of a high level of microfabrication and/or sophisticated instruments. Hence, this study is set to develop a simple DNA aptamer-enabled and fluorescence polarisation-based homogenous assay that eliminates the need to separate unbound detection ligands from the bound species for EV detection.
View Article and Find Full Text PDFLong-term survival of a patient with gastric cancer with bone marrow metastasis receiving S-1 plus oxaliplatin beyond three years: a case report and literature review.
Front Oncol
August 2024
Department of Medical Oncology/Hematology, Kakogawa Central City Hospital, Hyogo, Japan.
Background: Bone marrow metastasis (BMM) of gastric cancer (GC), which is the most common cause of disseminated intravascular coagulation (DIC) among solid tumors, has a poor prognosis. Studies on prognostic improvement beyond one year in patients with GC with BMM are limited. This is the first report of a patient who survived over three years after 30 months of S-1 plus oxaliplatin (SOX) therapy for GC with BMM.
View Article and Find Full Text PDFA 51-year-old woman with a 2-mm-Breslow-thickness melanoma on her arm had 99mTc-nanocolloid lymphoscintigraphy to localize the associated sentinel lymph node. A single axillary node was identified, and histology confirmed a micrometastasis of breast tissue origin. Imaging of the patient's breasts and subsequent biopsy confirmed ipsilateral stage III breast cancer, which was treated with lumpectomy and axillary node clearance.
View Article and Find Full Text PDFThe role of micrometastasis in high-risk skin cancers.
Australas J Dermatol
March 2024
Independent Scholar.
Article Synopsis
- The tendency for solid cancers to spread (metastasize) is crucial for determining patient prognosis, and recent findings show that micrometastases can develop much earlier than previously recognized.
- There is a complex interaction between blood vessel (vascular) and lymphatic spread of cancer cells that can begin before a primary tumor is even detectable, indicating cancer may be more systemic than localized.
- The current cancer staging methods may need updates to accurately reflect cancer presence in different areas of the body, and early therapies for small-scale cancer spread could help prevent more severe disease later on, especially in high-risk cases like skin cancer.
Integration of transcriptomics data into agent-based models of solid tumor metastasis.
Comput Struct Biotechnol J
March 2023
Laboratory of Systems Tumor Immunology, Department of Dermatology, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Recent progress in our understanding of cancer mostly relies on the systematic profiling of patient samples with high-throughput techniques like transcriptomics. With this approach, one can find gene signatures and networks underlying cancer aggressiveness and therapy resistance. However, omics data alone cannot generate insights into the spatiotemporal aspects of tumor progression.
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