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Gender differences in clinical presentations and sensory profiles in patients with fibromyalgia: implications of peripheral and central mechanisms.
Pain Rep
February 2025
Pain Management and Neuromodulation Centre, Guy's and St. Thomas' Hospital, London, United Kingdom.
Introduction: Fibromyalgia has a high female predominance and research work has been focussing mainly on women.
Objectives: We aimed to answer (1) gender differences in pain scores and quality of life, (2) any gender-specific subgroups defined by quantitative sensory testing (QST), and (3) correlations of QST parameters with pain intensity and questionnaire scores.
Methods: We evaluated clinical presentations and QST profiles from 38 male and 38 age-matched female patients.
Differences in Plasma BDNF Levels Between Chronic Primary Musculoskeletal Pain, Fibromyalgia Syndrome, and Asymptomatic Subjects: A Cross-Sectional Study.
Biol Res Nurs
January 2025
Cognitive Neuroscience, Pain and Rehabilitation Research Group (NECODOR), Faculty of Health Sciences, Rey Juan Carlos University, Alcorcón, Spain.
This cross-sectional study compared plasma brain-derived neurotrophic factor (BDNF) levels among chronic primary musculoskeletal pain patients, chronic widespread pain patients, and asymptomatic controls. The study included 126 participants aged 18-65, divided into three groups of 42 each. Pain intensity was assessed using a Numeric Rating Scale (NRS), and plasma BDNF levels were measured via ELISA.
View Article and Find Full Text PDFDo cytokines play a role in the transition from acute to chronic musculoskeletal pain?
Pharmacol Res
January 2025
University Hospital of Jena, Institute of Physiology 1, Jena D-07740, Germany. Electronic address:
Musculoskeletal pain has a high prevalence of transition to chronic pain and/or persistence as chronic pain for years or even a lifetime. Possible mechanisms for the development of such pain states are often reflected in inflammatory or neuropathic processes involving, among others, cytokines and other molecules. Since biologics such as blockers of TNF or IL-6 can attenuate inflammation and pain in a subset of patients with rheumatoid arthritis, the question arises to what extent cytokines are involved in the generation of pain in human musculoskeletal diseases.
View Article and Find Full Text PDFPineal cyst in bipolar patient with normolithiaemia and positive fibromyalgic tender points.
Radiol Case Rep
March 2025
Unit of Neurosurgery, Sant'Elia Hospital, via Luigi Russo n° 6, Caltanissetta, Italy.
Article Synopsis
- Pineal cysts are benign growths in the pineal gland often found accidentally during MRIs, usually causing no symptoms but can lead to neurological issues if they grow.
- The exact causes of these cysts are unclear, but factors like inflammation from conditions like fibromyalgia and mechanical stress may contribute, along with potential links to long-term lithium use in psychiatric treatment.
- A case study of a 49-year-old woman with bipolar disorder on lithium highlighted possible connections between cyst formation, systemic inflammation, and psychiatric conditions, indicating the need for more research on these interactions.
Pain and the perception of space in fibromyalgia.
Sci Rep
January 2025
NPSY.Lab-VR, Department of Human Sciences, University of Verona, Lungadige Porta Vittoria 17, Verona, Italy.
The Economy of action hypothesis postulates that bodily states rescale the perception of the individual's environment's spatial layout. The estimation of distances and slopes in navigation space (i.e.
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