Programmed electrostimulators of the sinocarotid nerves were implanted to 78 patients with bacterial asthma (BA) with a severe hormone-dependent course (age 18-67 years). Radiofrequency electrostimulation was performed daily for 6 years (impulse current, 30-150 Hz, 0.1-0.4 ms, 0.1-0.5 W. The regime was selected individually by the bronchodilating effect measured at pneumotachometry. The electrostimulation effectively arrested and prevented the majority of asphyxia attacks, reduced their frequency (2.7-fold) and need in medicines (2.7-3.4-fold). Serious complications were absent. Electrostimulation of the sinocarotid nerves can be applied in patients with bronchial asthma resistant to drug therapy, in side effects of glucocorticosteroids and adrenomimetic drugs.
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The vaso-renal arterial hypertension was produced in in the "two kidneys-one clip" model in experiments on Wistar male rats. This procedure was performed both in rats with intact mechanoreceptor zones of large vessels and the rats with destroyed baroreceptors. The date obtained indicate that in rats with cutting of "buffer" nerves the arterial hypertension after clipping renal artery occurred in all rats while in rats with intact sino-carotid and aortal nerves arterial hypertension developed only in 39% of the animals.
View Article and Find Full Text PDFBull Exp Biol Med
February 2005
Department of Normal Physiology, Samara State Medical University.
Hypoxia was followed by more pronounced activation of the respiratory center and pronounced hypotensive response after unilateral injection of nitric oxide synthase blocker L-NAME into the A5 region. Microinjection of exogenous nitric oxide donor sodium nitroprusside into the A5 region abolished the effect of L-NAME on hypoxia-induced changes in activity of the respiratory center and blood pressure. Bilateral transection of the vagal and sinocarotid nerves suppressed the response of the respiratory center to hypoxia.
View Article and Find Full Text PDFRom J Physiol
July 2005
University of Medicine and Pharmacy Cluj-Napoca, Dept. of Physiology.
The research activity upon erythropoiesis regulation carried out by the team in the Physiology Department and in the Institute of Medical Research of the Romanian Academy in Cluj-Napoca developed continuously after 1950. Our studies contributed to the isolation, identification and characterization of erythropoietin (Epo) and also to a better understanding of the nervous adaptation mechanisms to hypoxia. At present, it is well known that hypoxia acts upon erythropoiesis through Epo production.
View Article and Find Full Text PDFMethods of surgical treatment of bronchial asthma (BA) are classified as first generation (glomectomy, gangliectomy, vagotomy, pulmonary roots denervation), second generation (implantation of neurostimulators of sinocarotid, diaphragmal nerves, vagus, sympathic trunks), third generation (implants of programmed microchips). 7-year experience of surgical treatment with second generation methods in 125 patients with BA and experience of third generation methods use are summarized. Methods of second and third generations are most promising, permit to prevent and to cure asphyxia attack without drugs--with electrostimulation of vegetative system structures by impulse current (30-150 Hz, 0.
View Article and Find Full Text PDFProgrammed electrostimulators of the sinocarotid nerves were implanted to 78 patients with bacterial asthma (BA) with a severe hormone-dependent course (age 18-67 years). Radiofrequency electrostimulation was performed daily for 6 years (impulse current, 30-150 Hz, 0.1-0.
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